Department of Cardiology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, Jiangsu, China.
Department of Cardiovascular Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Clin Cardiol. 2024 Jun;47(6):e24276. doi: 10.1002/clc.24276.
The purpose of this study was to explore the association between triglycerides (TGs) and the risk of atrial fibrillation (AF) recurrence.
Included were adult patients with AF who underwent radiofrequency catheter ablation in the Affiliated Changzhou Second People's Hospital of Nanjing Medical University. The enrolled patients were divided into the AF recurrence group and the sinus rhythm (SR) maintenance group. The univariate Cox regression analysis and Kaplan-Meier survival curve were performed estimate the association between TG and the risk of AF recurrence. Of the 402 patients, 79 (19.7%) experienced recurrence of AF after ablation. The TG level was significantly higher in the AF recurrence group than in the SR-maintaining group. Patients were grouped by quartile of TG levels, with Quartile 1 and Quartile 2 defined as the low concentration group, Quartile 3 as the moderate concentration group, and Quartile 4 as the high concentration group. Multivariate Cox regression analysis showed that the moderate concentration group (p = .02, hazard ratio [HR]: 2.331, 95% confidence interval [CI]: 1.141-4.762) and high concentration group (p = .007, HR: 2.873, 95% CI: 1.332-6.199) were associated with an increased risk of AF recurrence compared with the low concentration group. The median follow-up was 1.17 years, it is indicated that a higher risk of recurrent AF was observed in the moderate concentration and high concentration group (log-rank: χ = 7.540, p = .023).
Our data suggest that an elevated TG level measured before catheter ablation is associated with an increased risk of AF recurrence.
本研究旨在探讨甘油三酯（TGs）与心房颤动（AF）复发风险的关系。
纳入在南京医科大学附属常州第二人民医院接受射频导管消融术的成年 AF 患者。将入组患者分为 AF 复发组和窦性节律（SR）维持组。采用单因素 Cox 回归分析和 Kaplan-Meier 生存曲线评估 TG 与 AF 复发风险的关系。在 402 例患者中，79 例（19.7%）消融后 AF 复发。AF 复发组的 TG 水平明显高于 SR 维持组。根据 TG 水平的四分位数将患者分组，第 1 四分位数和第 2 四分位数定义为低浓度组，第 3 四分位数为中浓度组，第 4 四分位数为高浓度组。多因素 Cox 回归分析显示，中浓度组（p = .02，风险比[HR]：2.331，95%置信区间[CI]：1.141-4.762）和高浓度组（p = .007，HR：2.873，95% CI：1.332-6.199）与低浓度组相比，AF 复发风险增加。中位随访时间为 1.17 年，中浓度组和高浓度组复发 AF 的风险较高（对数秩：χ = 7.540，p = .023）。
我们的数据表明，导管消融前测量的 TG 水平升高与 AF 复发风险增加相关。
