Scadding G K, Gray C, Conti D M, McDonald M, Backer V, Scadding G, Bernal-Sprekelsen M, De Corso E, Diamant Z, Hopkins C, Jesenak M, Johansen P, Kappen J, Mullol J, Price D, Quirce S, Reitsma S, Toppila-Salmi S, Senior B, Thyssen J P, Wahn U, Hellings P W
Department of Allergy & Rhinology, Royal National ENT Hospital, London, United Kingdom.
Division of Immunity and Infection, University College, London, United Kingdom.
Front Allergy. 2024 May 15;5:1404735. doi: 10.3389/falgy.2024.1404735. eCollection 2024.
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in addition to the need to improve population health via multiple measures, including reduction of exposure to allergens and pollutants and avoidance of obesity, there are several possible specific means to reduce asthma development in those most at risk (pre- asthma). The most obvious is allergen immunotherapy (AIT), which when given for allergic rhinitis (AR) has reasonable evidence to support asthma prevention in children (2) but also needs further study as primary prevention. In this second paper we explore the possibilities for similar actions in late onset eosinophilic asthma.
糖尿病前期的概念促使人们采取措施，通过识别糖尿病高危人群来降低疾病进展。我们之前曾探讨过与过敏性哮喘相关的哮喘前期概念，并认为，除了需要通过多种措施改善人群健康，包括减少接触过敏原和污染物以及避免肥胖外，还有几种可能的具体方法来降低高危人群（哮喘前期）患哮喘的风险。最明显的是变应原免疫疗法（AIT），用于治疗过敏性鼻炎（AR）时，有合理证据支持其对儿童哮喘的预防作用（2），但作为一级预防还需要进一步研究。在第二篇论文中，我们探讨了在迟发性嗜酸性粒细胞性哮喘中采取类似行动的可能性。
