弗里德虚弱表型在土耳其人群中的有效性和可靠性。
Validity and reliability of Fried frailty phenotype in Turkish population.
作者信息
Doğan Varan Hacer, Deniz Olgun, Çöteli Süheyla, Tuna Doğrul Rana, Kizilarslanoğlu Muhammet Cemal, Göker Berna
机构信息
Division of Geriatric Medicine, Department of Internal Medical Sciences, Faculty of Medicine, Gazi University, Ankara, Turkey.
出版信息
Turk J Med Sci. 2021 Oct 23;52(2):323-328. doi: 10.3906/sag-2105-165. eCollection 2022.
BACKGROUND/AIM: Frailty is an important, multidimensional geriatric syndrome defined as increased vulnerability to stressors. Fried frailty phenotype (FFP) is one of the most widely used models to define physical frailty. The aim of this study is to investigate the cross-cultural validity and reliability of Fried frailty phenotype (FFP) in older Turkish population.
MATERIALS AND METHODS
A total of 450 patients, aged 59 years and over, were included. FFP translated into Turkish was used. Hand grip strength cut-off values that best predict low skeletal muscle mass index (SMI) for Turkish men and women were calculated. A modified version of FFP was created by rescoring FFP according to these cut-off values applicable to Turkish population. Correlation analysis between the frailty assessment by comprehensive geriatric evaluation of clinician experienced in geriatric medicine, and FFP and modified version of FFP were performed for validation. Thirty-five patients underwent frailty assessment with FFP twice for reliability assessment. Inter-rater and intra-rater agreements were investigated.
RESULTS
Clinician's decision of frailty status demonstrated significant agreement with the results of FFP, as well as modified FFP. Interrater and intra-rater compliance were good. Best hand grip strength cut-off values for predicting low SMI in older Turkish population were determined as ≤13.6 kg (AUC: 0.841, p < 0.001) for women and ≤27.7 kg for men (AUC: 0.779; p < 0.001). Modified FFP had a good agreement with the FFP.
CONCLUSION
FFP is a valid and reliable tool for Turkish population.
背景/目的：衰弱是一种重要的、多维度的老年综合征，定义为对应激源的易感性增加。弗里德衰弱表型（FFP）是定义身体衰弱最广泛使用的模型之一。本研究的目的是调查弗里德衰弱表型（FFP）在土耳其老年人群中的跨文化有效性和可靠性。
材料与方法
共纳入450名年龄在59岁及以上的患者。使用翻译成土耳其语的FFP。计算出最能预测土耳其男性和女性低骨骼肌质量指数（SMI）的握力临界值。根据适用于土耳其人群的这些临界值对FFP重新评分，创建了FFP的修改版本。为了进行验证，对有老年医学经验的临床医生通过综合老年评估进行的衰弱评估与FFP及FFP修改版本之间进行了相关性分析。35名患者接受了两次FFP衰弱评估以进行可靠性评估。调查了评分者间和评分者内的一致性。
结果
临床医生对衰弱状态的判定与FFP以及修改后的FFP结果显示出显著一致性。评分者间和评分者内的一致性良好。确定预测土耳其老年人群低SMI的最佳握力临界值为女性≤13.6千克（AUC：0.841，p<0.001），男性≤27.7千克（AUC：0.779；p<0.001）。修改后的FFP与FFP有良好的一致性。
结论
FFP是适用于土耳其人群的有效且可靠的工具。
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