Şahiner Zeynep, Güner Merve, Balli Turhan Fatma Nisa, Ceylan Serdar, Okyar Baş Arzu, Hafizoğlu Merve, Karaduman Didem, Atbaş Cansu, Polat Özer Yasemin, Sönmezer Meliha Çağla, Balci Cafer, Doğu Burcu Balam, Cankurtaran Mustafa, İnkaya Ahmet Çağkan, Demirkan Kutay, Ünal Serhat, Halil Meltem Gülhan
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Department of Clinical Pharmacy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
J Clin Med. 2025 Aug 22;14(17):5941. doi: 10.3390/jcm14175941.
Bioelectrical impedance analysis has been used to evaluate phase angle, which predicts cellular health and may even predict survival in people living with HIV. However, the relationship between the phase angle and geriatric syndromes is unclear. This study aims to evaluate geriatric syndromes and how they interact with issues affecting HIV patients by conducting a full geriatric evaluation and comparing phase angles. Fifty people living with HIV and 52 participants without HIV were included in the study. All participants underwent a comprehensive geriatric assessment. BIA was used to determine the phase angle, which was then predicted from impedance measurements. The mean age of people living with HIV was 60.0 ± 12.0 years, and that of participants without HIV was 60.0 ± 5.0 years in participants without HIV ( = 0.93). The number of drugs used by people living with HIV infection was considerably higher than that used by those in the HIV-negative group ( = 0.018). There was a statistically significant difference in the phase angle between without HIV and with HIV. The median [interquartile range (IQR)] phase angle was 7.4 [4.0] degrees, and it was 5.7 [3.2] degrees ( = 0.004). Phase angle measurements between people living with HIV and without HIV could provide valuable insights into overall health status treatment response and prognosis. Further large-scale research is to corroborate our findings.
生物电阻抗分析已被用于评估相角，相角可预测细胞健康状况，甚至可能预测艾滋病毒感染者的生存情况。然而，相角与老年综合征之间的关系尚不清楚。本研究旨在通过进行全面的老年评估并比较相角，来评估老年综合征以及它们如何与影响艾滋病毒患者的问题相互作用。该研究纳入了50名艾滋病毒感染者和52名未感染艾滋病毒的参与者。所有参与者均接受了全面的老年评估。采用生物电阻抗分析（BIA）来确定相角，然后根据阻抗测量结果进行预测。艾滋病毒感染者的平均年龄为60.0±12.0岁，未感染艾滋病毒的参与者平均年龄为60.0±5.0岁（P = 0.93）。艾滋病毒感染者使用的药物数量明显高于艾滋病毒阴性组（P = 0.018）。未感染艾滋病毒者和感染艾滋病毒者之间的相角存在统计学显著差异。相角的中位数[四分位间距（IQR）]为7.4[4.0]度，而在艾滋病毒感染者中为5.7[3.2]度（P = 0.004）。艾滋病毒感染者和未感染者之间的相角测量可为整体健康状况、治疗反应和预后提供有价值的见解。进一步的大规模研究将证实我们的发现。
