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伟大的模仿者:梅毒皮肤表现的多样面孔。

The Great Imitator: The Many Faces of Syphilitic Skin Presentations.

作者信息

Basheer Mohamed Bushry, Mohamed Buhary Thajunnisha, Friday Dawn

机构信息

Medicine, Cambridge University Hospitals National Health Service (NHS) Trust, Cambridge, GBR.

Genitourinary Medicine, London North West University Healthcare National Health Service (NHS) Trust, London, GBR.

出版信息

Cureus. 2024 Apr 29;16(4):e59281. doi: 10.7759/cureus.59281. eCollection 2024 Apr.

DOI:10.7759/cureus.59281
PMID:38813282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11135388/
Abstract

We report the case of a 22-year-old heterosexual man presenting with a pruritic rash to the sexual health clinic. He was initially suspected of having a fungal rash by his general practitioner (GP) and treated with antifungals unsuccessfully. Subsequent testing revealed an active infection with . This was complicated by the concurrent fungal infection of the penile skin resulting in multiple lesions, requiring both antibiotic and antifungal treatment. With this case report, we hope to raise awareness amongst clinicians in non-traditional settings of the uncommon ways in which syphilis can present and to always consider it as a differential diagnosis, particularly in less likely populations.

摘要

我们报告了一名22岁异性恋男性的病例,他因出现瘙痒性皮疹前往性健康诊所就诊。他最初被全科医生怀疑患有真菌性皮疹,并接受了抗真菌治疗,但未成功。随后的检测显示感染了梅毒。同时阴茎皮肤合并真菌感染,导致多处皮损,这使病情变得复杂,需要同时进行抗生素和抗真菌治疗。通过本病例报告,我们希望提高非传统环境下临床医生对梅毒不常见表现方式的认识,并始终将其视为鉴别诊断之一,尤其是在可能性较小的人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/a11ff60b05f5/cureus-0016-00000059281-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/6de370f340da/cureus-0016-00000059281-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/f32383911fd1/cureus-0016-00000059281-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/a11ff60b05f5/cureus-0016-00000059281-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/6de370f340da/cureus-0016-00000059281-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/f32383911fd1/cureus-0016-00000059281-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f8/11135388/a11ff60b05f5/cureus-0016-00000059281-i03.jpg

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本文引用的文献

1
Malignant Syphilis: A Systematic Review of the Case Reports Published in 2014-2018.
Actas Dermosifiliogr (Engl Ed). 2021 May 17. doi: 10.1016/j.adengl.2021.05.014.
2
Papulosquamous eruption with ocular symptoms caused by syphilis.梅毒引起的伴有眼部症状的丘疹鳞屑性皮疹。
CMAJ. 2020 Dec 7;192(49):E1727. doi: 10.1503/cmaj.200820.
3
[Malignant syphilis in a patient with HIV infection].[一名HIV感染患者的恶性梅毒]
Medicina (B Aires). 2020;80(6):714-717.
4
The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity.梅毒的免疫病理生物学:梅毒的表现和病程由迟发型超敏反应的水平决定。
Am J Dermatopathol. 2011 Jul;33(5):433-60. doi: 10.1097/DAD.0b013e3181e8b587.