Soni Asmith K, Jha Roshan K
Medical Education, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Apr 28;16(4):e59234. doi: 10.7759/cureus.59234. eCollection 2024 Apr.
Since ancient times, several sorts of nanoparticles have been employed in the quickly expanding field of nanotechnology. These features include size, shape, and chemical as well as physical properties. Because of their small size and huge surface area, carbon-based nanoparticles, including fullerenes, carbon nanotubes, graphene, graphene oxide, and carbon-based quantum dots, have attracted a lot of attention in a variety of sectors, including biomedical applications. Lipid bilayers form the spherical vesicles known as liposomes. Magnetic resonance imaging (MRI) contrast agents are iron oxide nanoparticles. These materials are perfect for drug and delivery of genes, bioimaging, and bone repair because of their remarkable mechanical, electrical, visual, and chemical properties. However, concerns about potential asbestos-related diseases have arisen due to their length-to-width aspect ratio. Ceramic nanoparticles, on the other hand, are a common material in daily life and play a crucial role in bone repair, multiscale hybridisation, and aerospace structures. These nanoparticles can enhance osseointegration and bone development by mimicking the nanocomposition and nanoscale characteristics of bone tissue and enhance osteoconductive and osteoinductive capacities. Ceramic nanoparticles, however, have the potential to generate oxidative stress, which can result in irritation of the reticuloendothelial system, cytotoxicity to the heart, liver, and lungs, as well as toxicity to the cells that are attached. Additionally, oxidative stress, cell damage, and genotoxicity might result from the generation of free radicals by ceramic nanoparticles. Metal nanoparticles exhibit linear optical properties similar to molecular systems but arise from a different physical process. Semiconductor nanocrystals (NCs) are made from various compounds, such as silicon and germanium. Polyandry nanoparticles are particles approximately 10 and 10000 nanometers (nm) in size that can contain active substances. They have applications in vaccine delivery, gene therapy, and polymer nanoparticles (nanomedicine) for therapeutic applications.
自古以来,几种纳米颗粒已被应用于快速发展的纳米技术领域。这些特性包括尺寸、形状以及化学和物理性质。由于其尺寸小和表面积大,包括富勒烯、碳纳米管、石墨烯、氧化石墨烯和碳基量子点在内的碳基纳米颗粒在包括生物医学应用在内的各个领域引起了广泛关注。脂质双层形成了被称为脂质体的球形囊泡。磁共振成像(MRI)造影剂是氧化铁纳米颗粒。由于其卓越的机械、电学、视觉和化学性质,这些材料非常适合药物和基因递送、生物成像以及骨修复。然而,由于它们的长宽比,人们对潜在的石棉相关疾病产生了担忧。另一方面,陶瓷纳米颗粒是日常生活中的常见材料,在骨修复、多尺度杂交和航空航天结构中起着至关重要的作用。这些纳米颗粒可以通过模拟骨组织的纳米组成和纳米尺度特征来增强骨整合和骨发育,并增强骨传导和骨诱导能力。然而,陶瓷纳米颗粒有可能产生氧化应激,这可能导致网状内皮系统的刺激、对心脏、肝脏和肺部的细胞毒性以及对附着细胞的毒性。此外,陶瓷纳米颗粒产生的自由基可能导致氧化应激、细胞损伤和基因毒性。金属纳米颗粒表现出与分子系统相似的线性光学性质,但源于不同的物理过程。半导体纳米晶体(NCs)由各种化合物制成,如硅和锗。聚阴离子纳米颗粒是尺寸约为10至10000纳米(nm)的颗粒,可包含活性物质。它们在疫苗递送、基因治疗以及用于治疗应用的聚合物纳米颗粒(纳米医学)中有应用。