Ma Jing, Li Xue, Wang Chunru
Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2024 Dec 7;25(23):13158. doi: 10.3390/ijms252313158.
Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people's lives and health. To date, therapeutics with high therapeutic efficacy and low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatment. Here, we first introduce the diversity of nanomaterials and the effects of their different physicochemical properties on pancreatic function. Following this, we analyze the potential of nanomaterials to enhance pancreatic targeting by overcoming the challenges of traditional delivery methods through surface modifications, structural adjustments, and optimized drug loading. Then, we introduce the application of structurally optimized nanomaterials to pancreatic-related diseases. For instance, on pancreatic cancer (as drug delivery platforms, for the promotion of radiation therapy, and as multifunctional tools), pancreatitis (as drug delivery systems, anti-inflammatory and anti-fibrotic agents), and diabetes (as insulin delivery carriers, for protecting pancreatic β cells, and for improving insulin resistance). Through analysis of the progress of current research, we summarize how nanomaterials can enhance treatment efficacy while minimizing side effects. Finally, we look forward to the prospects of nanomaterials in pancreatic disease treatment.
胰腺疾病，通常包括胰腺癌、胰腺炎和糖尿病，对人们的生命和健康构成巨大威胁。迄今为止，开发具有高治疗效果和低副作用的疗法仍然具有挑战性。随着纳米技术的发展，纳米材料已成功应用于胰腺疾病的治疗。在此，我们首先介绍纳米材料的多样性及其不同物理化学性质对胰腺功能的影响。接下来，我们分析纳米材料通过表面修饰、结构调整和优化药物负载来克服传统递送方法的挑战，从而增强胰腺靶向性的潜力。然后，我们介绍结构优化的纳米材料在胰腺相关疾病中的应用。例如，在胰腺癌（作为药物递送平台、促进放射治疗以及作为多功能工具）、胰腺炎（作为药物递送系统、抗炎和抗纤维化剂）和糖尿病（作为胰岛素递送载体、保护胰腺β细胞以及改善胰岛素抵抗）方面的应用。通过分析当前研究的进展，我们总结了纳米材料如何在将副作用降至最低的同时提高治疗效果。最后，我们展望纳米材料在胰腺疾病治疗中的前景。
