School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Biomed Pharmacother. 2022 Jun;150:112951. doi: 10.1016/j.biopha.2022.112951. Epub 2022 Apr 18.
The current advancements in nanotechnology are as an outcome of the development of engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot of attention in biomedical field due to their significant inert nature, and nanoscale structures, with size similar to many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle characteristics such as size, shape, environment, aspect ratio, ease of synthesis and functionalization properties have led to numerous applications in various fields of biomedicine. These include targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, as well as the modulation of two or three applications. The current article also discusses about the various properties of metallic nanoparticles and their applications in cancer imaging and therapeutics. The associated bottlenecks related to their clinical translation are also discussed.
当前纳米技术的进展是工程纳米粒子发展的结果。各种金属纳米粒子已经被广泛探索用于各种生物医学应用。由于其显著的惰性性质和纳米级结构，与许多生物分子的大小相似，它们在生物医学领域引起了广泛关注。它们的固有特性包括电子、光学、物理化学和表面等离激元共振，可以通过改变某些颗粒特性来改变，例如大小、形状、环境、纵横比、易于合成和功能化特性，这导致了它们在生物医学的各个领域的许多应用。这些应用包括靶向药物输送、传感、光热和光动力治疗、成像以及两种或三种应用的调节。本文还讨论了金属纳米粒子的各种性质及其在癌症成像和治疗中的应用。还讨论了与它们的临床转化相关的各种瓶颈。
