在Δ8向Δ7甾醇异构酶受阻的酵母突变体中鉴定麦角甾-8,24(28)-二烯-3β,6α-二醇。
Identification of ergosta-8,24(28)-dien-3 beta,6 alpha-diol in A delta 8 goes to delta 7 sterol isomerase-blocked yeast mutant.
作者信息
Pierce A M, Pierce H D, Unrau A M, Oehlschlager A C, Woods R A
出版信息
Lipids. 1979 Oct;14(10):876-9. doi: 10.1007/BF02534132.
PMID:388135
Abstract
In addition to the monohydroxysterols found in the delta 8 goes to delta 7 isomerase-blocked Saccharomyces cerevisiae mutant erg 2, a noval dihydroxysterol, ergosta-8,24(38)-dien-3 beta,6 alpha-diol, was isolated. This sterol accumulated to the extent of 2.1% of the total sterol fraction when this mutant was treated with 23-azacholesterol, a known inhibitor of the 24-methylene-sterol-24(28)-reductase.
摘要
除了在δ8向δ7异构酶受阻的酿酒酵母突变体erg 2中发现的单羟基甾醇外，还分离出一种新型二羟基甾醇，即麦角甾-8,24(38)-二烯-3β,6α-二醇。当用已知的24-亚甲基甾醇-24(28)-还原酶抑制剂23-氮杂胆固醇处理该突变体时，这种甾醇在总甾醇组分中的积累量达到了2.1%。
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