Glew R H, Pavuk R A
J Clin Microbiol. 1985 Jan;21(1):8-11. doi: 10.1128/jcm.21.1.8-11.1985.
Two fully automated drug-monitoring systems, the Syva Autolab 6000 and the Beckman Auto ICS, were compared in terms of accuracy, precision, speed of operation, and cost effectiveness in the determination of gentamicin levels in serum. Within-run and between-run precision for both systems were acceptable (coefficient of variation, 2.0 to 6.9%), and patient sample comparisons resulted in an intermethod correlation coefficient of 0.96. When reference samples (prepared to contain 1.2 to 10 micrograms of gentamicin per ml) were assayed, the Syva Autolab 6000 obtained concentrations within 8% of expected values, whereas the Beckman Auto ICS reported values up to 17% higher than target values. In a time and cost comparison, reagent costs for the Beckman system were ca. 50% less than for the Syva Autolab 6000; the Syva system, however, determined patient results two to three times faster than the Beckman Auto ICS.
对两种全自动药物监测系统，即Syva Autolab 6000和贝克曼自动免疫化学系统（Beckman Auto ICS），在测定血清中庆大霉素水平时的准确性、精密度、操作速度和成本效益方面进行了比较。两种系统的批内和批间精密度均可接受（变异系数为2.0%至6.9%），患者样本比较得出方法间相关系数为0.96。当对参考样本（制备成每毫升含1.2至10微克庆大霉素）进行检测时，Syva Autolab 6000获得的浓度在预期值的8%以内，而贝克曼自动免疫化学系统报告的值比目标值高出多达17%。在时间和成本比较中，贝克曼系统的试剂成本比Syva Autolab 6000约低50%；然而，Syva系统测定患者结果的速度比贝克曼自动免疫化学系统快两到三倍。
