Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea.
Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, South Korea.
J Biomater Sci Polym Ed. 2024 Aug;35(12):1947-1962. doi: 10.1080/09205063.2024.2359789. Epub 2024 May 30.
The utilization of polymethyl methacrylate (PMMA) bone cement is employed for the purpose of stabilizing fractured vertebral bodies. The existence of a mechanical imbalance in hard polymethylmethacrylate (PMMA) bone cement has the potential to increase the likelihood of a fracture occurring in the neighbouring vertebral body. In order to reduce potential difficulties, the primary goal of this study is to investigate the potential benefits of increasing PMMA bone cement's bioactivity and lowering its elastic modulus. The incorporation of a 10% volume fraction of hyaluronic acid (HyA) and polyethylene glycol (PEG) into the bone cement led to an improvement in the bioactivity and decreasing of elastic modulus of polymethylmethacrylate (PMMA). The integration of HyPE gel phase presents several advantages over pure PMMA bone cement, including enhanced setting parameters, improved degradability, and increased biocompatibility. The gel phase is additionally accountable for a reduction in the elastic modulus of polymethylmethacrylate (PMMA) bone cement. In addition, the existence of a porous structure that arises from the degradation of the HyPE gel phase delivers a significant amount of room, thereby enhancing the process of bone regeneration when implanted in the femur of rabbits. The utilization of HyPE in PMMA has been shown through comprehensive µ-CT analysis to enhance bone formation, thereby promoting osteointegration at the implantation site. Furthermore, the histological analysis demonstrated the existence of osteogenic activity in the PMMA polyethylene glycol supplemented with 10% HyA and 10% PEG after a 2-month period subsequent to implantation.
聚甲基丙烯酸甲酯（PMMA）骨水泥的应用目的是稳定骨折的椎体。在硬聚甲基丙烯酸甲酯（PMMA）骨水泥中存在机械不平衡，这有可能增加相邻椎体骨折的可能性。为了减少潜在的困难，本研究的主要目的是研究提高 PMMA 骨水泥的生物活性和降低其弹性模量的潜在益处。将 10%体积分数的透明质酸（HyA）和聚乙二醇（PEG）掺入骨水泥中，提高了聚甲基丙烯酸甲酯（PMMA）的生物活性和降低了弹性模量。HyPE 凝胶相的结合与纯 PMMA 骨水泥相比具有若干优势，包括改善的凝固参数、提高的降解性和增加的生物相容性。凝胶相还降低了聚甲基丙烯酸甲酯（PMMA）骨水泥的弹性模量。此外，由于 HyPE 凝胶相的降解而产生的多孔结构为骨再生提供了大量空间，从而增强了在兔子股骨中植入时的骨再生过程。通过全面的 µ-CT 分析表明，PMMA 中的 HyPE 增强了骨形成，从而促进了植入部位的骨整合。此外，组织学分析表明，在植入后 2 个月，补充有 10%HyA 和 10%PEG 的 PMMA 聚乙二醇中存在成骨活性。
