Chen Lei, Tang Yufei, Zhao Kang, Zha Xiang, Liu Jiaxin, Bai Hao, Wu Zixiang
School of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
School of Materials Science and Engineering, Xi'an University of Technology, Xi'an 710048, PR China.
Colloids Surf B Biointerfaces. 2019 Nov 1;183:110448. doi: 10.1016/j.colsurfb.2019.110448. Epub 2019 Aug 21.
High mechanical property especially the exorbitant elastic modulus is the common complication of the clinical polymethylmethacrylate (PMMA) bone cement which will generate the fracture of the adjacent bone and even aseptic loosening, other side effects including excess thermal temperature and low efficiency of the drug release bother the development of the PMMA bone cement. The present study aims to investigate the optimum dosage of gelatin as the porogen, which reduced the elastic modulus of the bone cement to the relatively close level of the cancellous bone. Meanwhile, better antibiotic release profile was introduced by enhancing the specific surface area and interconnectivity than the neat PMMA bone cement. Compared to the PMMA bone cement, the mechanical and thermal property was successfully reduced by the porous structure, the component with 200-400 μm gelatin has the better porosity which resulted in the increasing drug release amount and rate than that of the PMMA bone cement. Furthermore, data analysis and fitting curve could guide experiments, in turn, to obtain the PMMA bone cement with specific requirements of the mechanical properties by the addition of gelatin as the pore-forming agent, and in some cases for predictive purposes, to estimate how a change of gelatin may affect the porosity, mechanical properties, and drug release profiles.
高机械性能尤其是过高的弹性模量是临床聚甲基丙烯酸甲酯（PMMA）骨水泥常见的并发症，这会导致相邻骨骼骨折甚至无菌性松动，其他副作用包括过高的热温度和药物释放效率低，这些问题困扰着PMMA骨水泥的发展。本研究旨在研究明胶作为致孔剂的最佳用量，将骨水泥的弹性模量降低到与松质骨相对接近的水平。同时，通过提高比表面积和连通性，引入了比纯PMMA骨水泥更好的抗生素释放曲线。与PMMA骨水泥相比，多孔结构成功降低了其机械性能和热性能，含200 - 400μm明胶的组分具有更好的孔隙率，导致药物释放量和速率比PMMA骨水泥增加。此外，数据分析和拟合曲线可以指导实验，进而通过添加明胶作为成孔剂获得具有特定机械性能要求的PMMA骨水泥，并且在某些情况下用于预测目的，估计明胶的变化如何影响孔隙率、机械性能和药物释放曲线。
