Bazelmans J, Nestel P J, O'Dea K, Esler M D
Metabolism. 1985 Feb;34(2):154-60. doi: 10.1016/0026-0495(85)90125-8.
We have previously reported in lean subjects a significant relationship between plasma norepinephrine metabolism and energy state. The present study has examined in six obese men the response in plasma norepinephrine flux to ten day periods of overeating (+ 1000 kcal/m2 above isocaloric requirements) or undereating (400 kcal/d). Despite significant gains or losses in body weight, norepinephrine flux, measured during constant infusions of 3H-l-norepinephrine, failed to change significantly. Measurements of glucose utilization during constant infusions of insulin, showed significant changes with changing energy state, falling with overeating and rising with undereating. Insulin sensitivity was not correlated with plasma norepinephrine metabolism.
我们之前曾报道，在瘦人受试者中，血浆去甲肾上腺素代谢与能量状态之间存在显著关系。本研究对六名肥胖男性进行了检测，观察他们在连续十天暴饮暴食（比等热量需求高1000千卡/平方米）或节食（400千卡/天）期间血浆去甲肾上腺素通量的反应。尽管体重有显著增加或减少，但在持续输注3H-1-去甲肾上腺素期间测得的去甲肾上腺素通量并未发生显著变化。在持续输注胰岛素期间对葡萄糖利用情况的测量显示，随着能量状态的变化有显著改变，暴饮暴食时下降，节食时上升。胰岛素敏感性与血浆去甲肾上腺素代谢无关。
