Department of Psychology, College of Sciences, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA.
San Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, San Diego, CA, 92120, USA.
AIDS Behav. 2024 Aug;28(8):2804-2820. doi: 10.1007/s10461-024-04374-3. Epub 2024 May 31.
This randomized controlled study assessed the feasibility, acceptability, and preliminary impact of the PrEP iT! mHealth intervention designed to improve PrEP adherence among young men who have sex with men (YMSM). A national sample of 80 YMSM in the U.S. (M = 25 years; 54% racial/ethnic minority), recruited through social media ads, were randomized to either the PrEP iT! or usual PrEP care conditions. Participants completed online surveys and submitted self-collected dried blood sample (DBS) data as measures of PrEP adherence. Differences in PrEP adherence across treatment arms and between participants with high versus low engagement in PrEP iT! were assessed. Retention was high at the three (94%) and six (93%) month assessment, and participants in PrEP iT! reported satisfactory acceptability of the intervention. There were no significant differences in self-reported or DBS-derived PrEP adherence between randomized groups. However, YMSM in the PrEP iT! group with high PrEP adherence (the equivalent of four or more doses/week through self-report and DBS-derived measures) demonstrated significantly higher engagement in the intervention than those with low PrEP adherence (the equivalent of 3 or fewer doses/week). Overall, the PrEP iT! intervention demonstrated strong feasibility and acceptability. The finding that high PrEP iT! intervention engagement was associated with protective levels of PrEP adherence suggests it is a viable adherence support tool that should be further evaluated in definitive trial among YMSM who need basic support, or as part of a more comprehensive adherence support package for those who need greater assistance.Trial registration Clinical Trials # NCT04509076 (registered August 10, 2020).
这项随机对照研究评估了 PrEP iT！mHealth 干预措施的可行性、可接受性和初步效果，该措施旨在提高男男性行为者 (MSM) 的 PrEP 依从性。研究在美国招募了 80 名 MSM（M=25 岁；54%为少数族裔）作为研究对象，他们通过社交媒体广告被随机分配到 PrEP iT！或常规 PrEP 护理条件组。参与者完成了在线调查，并提交了自我采集的干血斑 (DBS) 数据，作为 PrEP 依从性的衡量标准。评估了治疗组之间和 PrEP iT！高参与度与低参与度参与者之间的 PrEP 依从性差异。在三个月和六个月的评估中，保留率分别高达 94%和 93%，并且参与者对干预措施的可接受性表示满意。通过自我报告和 DBS 测量，随机分组的 PrEP 依从性之间没有显著差异。然而，在 PrEP iT！组中，高 PrEP 依从性（自我报告和 DBS 测量均为每周四或更多剂）的 MSM 比低 PrEP 依从性（每周三或更少剂）的 MSM 对干预措施的参与度显著更高。总体而言，PrEP iT！干预措施具有很强的可行性和可接受性。高 PrEP iT！干预措施参与度与保护水平的 PrEP 依从性相关的发现表明，它是一种可行的依从性支持工具，应该在需要基本支持的 MSM 中进行更严格的临床试验评估，或者作为那些需要更大帮助的人的更全面的依从性支持方案的一部分进行评估。试验注册 临床试验 # NCT04509076（2020 年 8 月 10 日注册）。
