5种噻唑化合物在沙门氏菌/微粒体和小鼠淋巴瘤TK+/-试验中的诱变活性。

Mutagenic activity of 5 thiazole compounds in the Salmonella/microsome and mouse lymphoma TK+/- assays.

作者信息

Cameron T P, Hughes T J, Kirby P E, Palmer K A, Fung V A, Dunkel V C

出版信息

Mutat Res. 1985 Jan-Feb;155(1-2):17-25. doi: 10.1016/0165-1218(85)90020-5.

Abstract

To aid in the selection of chemical candidates for in vivo tests, the mutagenicity of 5 thiazole compounds was evaluated in the Salmonella plate incorporation assay and mouse lymphoma L5178Y TK+/- assay. Two of the compounds, 2-thiazolamine and 3-methyl-5-isothiazolamine, were positive in both assays; and one, thiazole, was negative. With the other 2 compounds the results were nonconcordant: 5-phenyl-2,4-thiazolediamine was negative in the Salmonella assay but positive in the mouse lymphoma assay, and C.I. Basic Red 29 was positive in the Salmonella assay while the response in the mouse lymphoma assay was considered equivocal.

摘要

为协助体内试验化学候选物的筛选，在沙门氏菌平板掺入试验和小鼠淋巴瘤L5178Y TK+/-试验中评估了5种噻唑化合物的致突变性。其中两种化合物，2-噻唑胺和3-甲基-5-异噻唑胺，在两种试验中均呈阳性；而噻唑呈阴性。另外两种化合物的结果不一致：5-苯基-2,4-噻唑二胺在沙门氏菌试验中呈阴性，但在小鼠淋巴瘤试验中呈阳性，碱性红29在沙门氏菌试验中呈阳性，而在小鼠淋巴瘤试验中的反应被认为不明确。