Aljohani Amal, Rashwan Noha, Vasani Shruti, Alkhawashki Ahmed, Wu Tong Tong, Lu Xingyi, Castillo Daniel A, Xiao Jin
Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Pediatrics, King Fahd Medical City, Riyadh, Saudi Arabia.
Probiotics Antimicrob Proteins. 2024 May 31. doi: 10.1007/s12602-024-10287-3.
To ensure effective administration of probiotics in clinical practice, it is crucial to comprehend the specific strains and their association with human health. Therefore, we conducted a systematic review and meta-analysis to evaluate the scientific evidence on the impact of Lactiplantibacillus plantarum probiotic consumption on human health. Out of 11,831 records, 135 studies were assessed qualitatively, and 18 studies were included in the meta-analysis. This systematic review demonstrated that probiotic supplementation with L. plantarum, either alone or in combination, can significantly improve outcomes for patients with specific medical conditions. Meta-analysis revealed notable benefits in periodontal health, evidenced by reduced pocket depth and bleeding on probing (p < 0.001); in gastroenterological health, marked by significant reductions in abdominal pain (p < 0.001); and in infectious disease, through a reduction in C-reactive protein levels (p < 0.001). Cardiovascular benefits included lowered total cholesterol and low-density lipoprotein cholesterol in the L. plantarum intervention group (p < 0.05). Our study's clinical significance highlights the importance of considering probiotic strain and their application to specific diseases when planning future studies and clinical interventions, emphasizing the need for further research in this area.
为确保益生菌在临床实践中的有效应用，了解特定菌株及其与人类健康的关联至关重要。因此，我们进行了一项系统综述和荟萃分析，以评估食用植物乳杆菌益生菌对人类健康影响的科学证据。在11831条记录中，对135项研究进行了定性评估，18项研究纳入了荟萃分析。这项系统综述表明，单独或联合补充植物乳杆菌益生菌，可显著改善特定疾病患者的预后。荟萃分析显示，在牙周健康方面有显著益处，表现为牙周袋深度降低和探诊出血减少（p<0.001）；在胃肠健康方面，显著减轻腹痛（p<0.001）；在传染病方面，C反应蛋白水平降低（p<0.001）。心血管方面的益处包括植物乳杆菌干预组的总胆固醇和低密度脂蛋白胆固醇降低（p<0.05）。我们研究的临床意义凸显了在规划未来研究和临床干预时，考虑益生菌菌株及其在特定疾病中的应用的重要性，强调了该领域进一步研究的必要性。
