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维生素 D 受体基因多态性与不孕风险的关联：系统评价和荟萃分析。

Association of vitamin D receptor genetic polymorphisms with the risk of infertility: a systematic review and meta-analysis.

机构信息

Student of the Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

出版信息

BMC Pregnancy Childbirth. 2024 May 30;24(1):398. doi: 10.1186/s12884-024-06590-0.

DOI:10.1186/s12884-024-06590-0
PMID:38816754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11138068/
Abstract

BACKGROUND

The causes of infertility have remained an important challenge. The relationship between VDR gene polymorphisms and infertility has been reported, with controversial findings.

OBJECTIVE AND RATIONALE

We aimed to determine this relationship by conducting a systematic review and meta-analysis.

SEARCH METHODS

The study was started with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) declaration and the final draft was registered as a protocol in PROSPERO (ID: CRD42023416535). The international electronic databases including PubMed (Medline), Scopus, Web of Sciences, and Cumulative Index to Nursing and Allied Health Literature (CINHAL) were searched until January 30, 2023, by using appropriate keywords. The quality of the final studies was assessed using the NOS Checklist for case-control studies. The odds ratios (ORs) for each of the genetic models were pooled, and a subgroup analysis based on geographical region and types of infertility was carried out by the MetaGenyo online tool.

OUTCOMES

Case-control studies including 18 and 2 studies about infertility in women and men, respectively, and 4 miscarriage studies were entered into the meta-analysis. The VDR gene TaqI polymorphism was associated with infertility susceptibility in women in the allele contrast [OR = 1.2065, 95% CI (1.0846-1.3421); P = 0.0005], Recessive model [OR = 1.3836, 95% CI (1.1197-1.7096); P = 0.002], Dominant model [OR = 1.2146, 95% CI (0.0484-1.4072); P = 0.009], Homozygote [OR = 1.4596, 95% CI (1.1627-1.8325); P = 0.001], and TT vs. Tt [OR = 1.2853, 95% CI (1.0249-1.6117); P = 0.029. ApaI and FokI gene polymorphisms were found to be significantly protective SNPs against women and men infertility in the Dominant model [OR = 0.8379, 95% CI (0.7039- 0.9975); P = 0.046] and Recessive model [OR = 0.421, 95% CI (0.1821-0.9767); P = 0.043], respectively. Sub-group meta-analysis showed a protection association of ApaI in dominant [OR = 0.7738, 95% CI = 0.6249-0.9580; P = 0.018] and AA vs. aa [OR = 0.7404, 95 CI% (0.5860-0.9353) P = 0.011725] models in PCOS subgroup, however, a negative association with idiopathic infertility was found in AA vs. Aa [OR = 1.7063, 95% CI (1.1039-2.6375); P = 0.016187] and Aa vs. aa [OR = 0.6069, 95% CI (0.3761-0.9792); P = 0.040754]. TaqI SNP was significantly associated with infertility in the African population and BsmI was associated with the disease mostly in the Asian population.

CONCLUSION

This meta-analysis showed that the TaqI polymorphism may be linked to women's infertility susceptibility. However, ApaI and FokI might be the protective SNPs against infertility in Women and men, respectively.

摘要

背景

不孕的原因仍然是一个重要的挑战。已经有报道称维生素 D 受体（VDR）基因多态性与不孕之间存在关系，但研究结果存在争议。

目的和理由

我们旨在通过系统评价和荟萃分析来确定这种关系。

研究方法

本研究按照系统评价和荟萃分析的首选报告项目（PRISMA）声明开始，并在 PROSPERO（ID：CRD42023416535）中注册为方案。使用适当的关键词，在国际电子数据库中检索包括 PubMed（Medline）、Scopus、Web of Sciences 和 Cumulative Index to Nursing and Allied Health Literature（CINHAL）在内的数据库，直到 2023 年 1 月 30 日。使用病例对照研究的 NOS 清单评估最终研究的质量。使用 MetaGenyo 在线工具根据地理位置和不孕类型进行亚组分析，对每种遗传模型的优势比（OR）进行汇总。

结果

纳入了 18 项关于女性不孕和 2 项关于男性不孕的病例对照研究，以及 4 项关于流产的研究。VDR 基因 TaqI 多态性与女性不孕易感性相关，在等位基因对比中 [OR=1.2065，95%CI（1.0846-1.3421）；P=0.0005]、隐性模型 [OR=1.3836，95%CI（1.1197-1.7096）；P=0.002]、显性模型 [OR=1.2146，95%CI（0.0484-1.4072）；P=0.009]、纯合子 [OR=1.4596，95%CI（1.1627-1.8325）；P=0.001]和 TT 与 Tt 相比 [OR=1.2853，95%CI（1.0249-1.6117）；P=0.029]。ApaI 和 FokI 基因多态性在显性模型中被发现是女性和男性不孕的保护性 SNP [OR=0.8379，95%CI（0.7039-0.9975）；P=0.046]和隐性模型 [OR=0.421，95%CI（0.1821-0.9767）；P=0.043]，分别。亚组荟萃分析显示，ApaI 在显性模型中具有保护作用 [OR=0.7738，95%CI（0.6249-0.9580）；P=0.018]和 AA 与 aa 相比 [OR=0.7404，95%CI%（0.5860-0.9353）；P=0.011725]，在 PCOS 亚组中具有保护作用，而在特发性不孕中，AA 与 Aa 相比 [OR=1.7063，95%CI（1.1039-2.6375）；P=0.016187]和 Aa 与 aa 相比 [OR=0.6069，95%CI（0.3761-0.9792）；P=0.040754]，与疾病具有负相关。TaqI SNP 与非洲人群的不孕相关，BsmI SNP 与亚洲人群的不孕相关。

结论

本荟萃分析表明 TaqI 多态性可能与女性不孕易感性相关。然而，ApaI 和 FokI 可能分别是女性和男性不孕的保护性 SNP。

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2
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Gynecol Endocrinol. 2021;37(sup1):8-12. doi: 10.1080/09513590.2021.2006451.
3
Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss.流产不容忽视：早期妊娠丢失的流行病学、身体、心理和经济成本。
Lancet. 2021 May 1;397(10285):1658-1667. doi: 10.1016/S0140-6736(21)00682-6. Epub 2021 Apr 27.
4
A novel update on vitamin D in recurrent pregnancy loss (Review).关于复发性妊娠丢失中维生素 D 的最新研究进展（综述）。
Mol Med Rep. 2021 May;23(5). doi: 10.3892/mmr.2021.12021. Epub 2021 Mar 24.
5
Vitamin D receptor gene polymorphisms and haplotypes in the etiology of recurrent miscarriages.维生素 D 受体基因多态性及其单体型与复发性流产的病因学。
Sci Rep. 2021 Feb 25;11(1):4646. doi: 10.1038/s41598-021-84317-3.
6
Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage.维生素 D 的蜕膜和胎盘代谢改变可能导致自然流产的病因。
Placenta. 2020 Mar;92:1-8. doi: 10.1016/j.placenta.2020.01.013. Epub 2020 Jan 26.
7
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Acta Clin Croat. 2019 Sep;58(3):508-515. doi: 10.20471/acc.2019.58.03.15.
8
Posttraumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multicenter, prospective, cohort study.流产和异位妊娠后创伤后应激、焦虑和抑郁：一项多中心、前瞻性队列研究。
Am J Obstet Gynecol. 2020 Apr;222(4):367.e1-367.e22. doi: 10.1016/j.ajog.2019.10.102. Epub 2019 Dec 13.
9
Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.维生素 D 在妊娠及妊娠以外时期的免疫调节作用
Front Immunol. 2019 Nov 22;10:2739. doi: 10.3389/fimmu.2019.02739. eCollection 2019.
10
Genetic variation in the maternal vitamin D receptor FokI gene as a risk factor for recurrent pregnancy loss.母体维生素 D 受体 FokI 基因遗传变异与复发性流产的风险因素。
J Matern Fetal Neonatal Med. 2021 Jul;34(14):2221-2226. doi: 10.1080/14767058.2019.1660768. Epub 2019 Sep 16.