Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Clin Exp Dermatol. 2019 Jul;44(5):498-505. doi: 10.1111/ced.13823. Epub 2018 Nov 25.
Vitamin D is considered a regulator of the immune system, and its polymorphisms have been associated with psoriasis in some but not all reports.
To explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to psoriasis.
Meta-analyses were conducted to determine the associations between psoriasis and the VDR ApaI, TaqI, BsmI and FokI polymorphisms in all participants, and stratified by ethnic group.
In total, 16 studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 2086 patients and 2182 controls. The meta-analysis indicated an association between psoriasis and the VDR TaqI TT genotype in Caucasian (OR = 1.29, 95% CI = 1.00-1.66, P < 0.05), but not in Asian (OR = 1.32, 95% CI = 0.89-1.96, P = 0.16) populations. However, no association was found between psoriasis and the VDR TaqI polymorphism using dominant, allele contrast or homozygous contrast models. No association was found between psoriasis and either the VDR ApaI, BsmI or FokI polymorphisms by meta-analyses of the allele contrast, recessive, or dominant models or homozygous contrast models in the overall, Caucasian or Asian populations.
This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations.
维生素 D 被认为是免疫系统的调节剂，其多态性与一些而非所有报道的银屑病有关。
探讨维生素 D 受体（VDR）多态性是否与银屑病易感性相关。
进行荟萃分析以确定 VDR ApaI、TaqI、BsmI 和 FokI 多态性与所有参与者银屑病易感性之间的关联，并按种族进行分层。
共有 16 项关于 VDR 多态性与银屑病的研究纳入了本荟萃分析，涉及 2086 例患者和 2182 例对照。荟萃分析表明，VDR TaqI TT 基因型与白种人银屑病之间存在关联（OR=1.29，95%CI=1.00-1.66，P<0.05），但与亚洲人无关（OR=1.32，95%CI=0.89-1.96，P=0.16）。然而，在显性、等位基因对比或纯合子对比模型中，未发现 VDR TaqI 多态性与银屑病之间存在关联。在总体、白种人和亚洲人群中，通过等位基因对比、隐性、显性或纯合子对比模型的荟萃分析，未发现 VDR ApaI、BsmI 或 FokI 多态性与银屑病之间存在关联。
本荟萃分析表明，VDR ApaI、BsmI 和 FokI 多态性与总体、白种人和亚洲人群的银屑病易感性无关。然而，VDR TaqI 多态性与白种人群的银屑病易感性相关。
