Yang Na, He Li-Yun, Li Zi-Yi, Yang Yu-Cheng, Ping Fan, Xu Ling-Ling, Li Wei, Zhang Hua-Bing, Li Yu-Xiu
Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
World J Clin Cases. 2024 May 26;12(15):2568-2577. doi: 10.12998/wjcc.v12.i15.2568.
The measurement of triceps skinfold (TSF) thickness serves as a noninvasive metric for evaluating subcutaneous fat distribution. Despite its clinical utility, the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly investigated.
To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause mortality.
This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition Survey. Latent class trajectory modeling was employed to identify distinct trajectories of TSF thickness. Subjects were classified into subgroups reflective of their respective TSF thickness trajectory. We utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality, including contributory factors.
Upon adjustment for multiple confounding factors, we discerned that males in the 'Class 2: Thin-stable' and 'Class 3: Thin-moderate' TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the 'Class 1: Extremely thin' subgroup. In the mediation analyses, the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and mortality. For females, a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly cohort.
In males and non-elderly females, lower TSF thickness trajectories are significantly predictive of heightened mortality risk, independent of single-point TSF thickness, body mass index, and waist circumference.
三头肌皮褶（TSF）厚度测量是评估皮下脂肪分布的一种非侵入性指标。尽管其具有临床实用性，但TSF厚度轨迹及其与全因死亡率的相关性尚未得到充分研究。
探讨中国成年人的TSF厚度轨迹，并检验其与全因死亡率的关联。
本研究纳入了来自中国健康与营养调查的14747名成年人队列。采用潜在类别轨迹模型来识别TSF厚度的不同轨迹。根据各自的TSF厚度轨迹将受试者分为亚组。我们利用多变量Cox回归分析和中介检验来探讨TSF厚度轨迹与全因死亡率之间的联系，包括促成因素。
在对多个混杂因素进行调整后，我们发现，与“第1类：极度消瘦”亚组相比，处于“第2类：消瘦-稳定”和“第3类：消瘦-中度”TSF厚度轨迹的男性全因死亡风险显著降低。在中介分析中，老年营养风险指数被发现是TSF厚度轨迹与死亡率之间关系的部分中介因素。对于女性，较低的TSF厚度模式仅在非老年队列中显著预测全因死亡风险升高。
在男性和非老年女性中，较低的TSF厚度轨迹显著预测较高的死亡风险，独立于单点TSF厚度、体重指数和腰围。
