Du Rongrong, Zhu Yahui, Chen Peng, Li Mao, Zhang Ying, Huang Xusheng
Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
School of Medicine, Nankai University, Tianjin, China.
Front Aging Neurosci. 2024 May 16;16:1357070. doi: 10.3389/fnagi.2024.1357070. eCollection 2024.
Obstructive sleep apnea (OSA) had a high prevalence in the population. Whether OSA increases the risk of amyotrophic lateral sclerosis (ALS) is unknown. Our aim was to clarify this issue using two-sample Mendelian randomization (MR) analysis in a large cohort.
Two-sample MR was used to evaluate the potential causality between OSA and ALS by selecting single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) from genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was chosen as the primary method to estimate causal association. Weighted median, weighted mode and simple mode methods were used as sensitivity analyses to ensure the robustness of the results.
In MR analysis, IVW mode showed genetic liability to OSA was found to be significantly associated with a higher ALS risk (OR, 1.220; 95% confidence interval, 1.031-1.443; = 0.021). No evidence of heterogeneity and horizontal pleiotropy were suggested.
We found potential evidence for a causal effect of OSA on an increased risk of ALS.
阻塞性睡眠呼吸暂停（OSA）在人群中具有较高的患病率。OSA是否会增加肌萎缩侧索硬化症（ALS）的风险尚不清楚。我们的目的是在一个大型队列中使用两样本孟德尔随机化（MR）分析来阐明这个问题。
通过从全基因组关联研究（GWAS）中选择单核苷酸多态性（SNP）作为工具变量（IV），使用两样本MR来评估OSA与ALS之间的潜在因果关系。选择逆方差加权（IVW）方法作为估计因果关联的主要方法。使用加权中位数、加权模式和简单模式方法作为敏感性分析，以确保结果的稳健性。
在MR分析中，IVW模式显示，OSA的遗传易感性与较高的ALS风险显著相关（OR，1.220；95%置信区间，1.031 - 1.443；P = 0.021）。未发现异质性和水平多效性的证据。
我们发现了OSA对ALS风险增加有因果效应的潜在证据。
