Jackson Sarah S, Lex Marina, De Wyngard Vanessa Van, Cook Paz, Hildesheim Allan, Pinto Ligia A, Jackson Sharon H, Choi Kelvin, Minas Tsion Zewdu, Losada Morales Héctor Fabio, Araya Juan Carlos, Ferreccio Catterina, Koshiol Jill, Pfeiffer Ruth M
Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD, USA.
Department of Mathematics, The Technical University of Munich, Munich, Germany.
Future Sci OA. 2024 May 15;10(1):2340327. doi: 10.2144/fsoa-2023-0032. eCollection 2024.
Statins are associated with lower risk of gallstones due to anti-inflammatory effects. We assessed whether statins impact circulating inflammation among Chilean women with gallstones. 200 Mapuche women were matched on statin use and age to 200 non-Mapuche women in the Chile Biliary Longitudinal Study. We analyzed 92 inflammatory biomarkers using multivariable-adjusted regression models, random forests and pathway analyses. Statins were not significantly associated with any inflammation marker when women were analyzed jointly or stratified by ancestry. No significant associations were found through random forest methods and pathway analyses. We did not find significant associations between statin use and inflammation markers in women with gallstones, suggesting that statins do not reduce inflammation once gallstones have formed.
由于具有抗炎作用，他汀类药物与胆结石风险降低有关。我们评估了他汀类药物是否会影响智利胆结石女性的循环炎症水平。在智利胆道纵向研究中，200名马普切族女性与200名非马普切族女性在他汀类药物使用情况和年龄方面进行了匹配。我们使用多变量调整回归模型、随机森林和通路分析方法分析了92种炎症生物标志物。当对女性进行联合分析或按血统分层分析时，他汀类药物与任何炎症标志物均无显著关联。通过随机森林方法和通路分析也未发现显著关联。我们没有发现胆结石女性使用他汀类药物与炎症标志物之间存在显著关联，这表明胆结石形成后他汀类药物不会减轻炎症。
