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采用化疗、免疫治疗和靶向治疗的转移性成人肾母细胞瘤：一例报告

Metastatic adult Wilms' tumor managed by chemotherapy, immunotherapy and target therapy: a case report.

作者信息

Zhao Qian, Xiong Qi, Song Qi

机构信息

Department of Oncology, Dandong First Hospital, 118000, Liaoning, China.

Department of Oncology, Chinese PLA General Hospital, 100080, Beijing, China.

出版信息

Future Sci OA. 2024 May 16;10(1):FSO915. doi: 10.2144/fsoa-2023-0156. eCollection 2024.

DOI:10.2144/fsoa-2023-0156
PMID:38817367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11137782/
Abstract

Wilms' tumor is a rare type of tumor in adult. Herein, we reported a case of 37-year-old female with adult Wilms' tumor (AWT) admitted in our institution. After a multidisciplinary team discussion, she underwent receiving immunotherapy plus chemotherapy and VEGF-targeted therapy. The tumor got smaller obviously after eight cycles of treatment. Our present case suggested that immunotherapy and anti-angiogenesis combined with chemotherapy is promising new approach for treating AWT. Moreover, we review the literatures reporting AWT with the purpose to improve the understanding of AWT treatment.

摘要

肾母细胞瘤在成人中是一种罕见的肿瘤类型。在此，我们报告了一例37岁成年女性肾母细胞瘤（AWT）患者入住我院的病例。经过多学科团队讨论后，她接受了免疫治疗加化疗以及VEGF靶向治疗。经过八个周期的治疗后，肿瘤明显缩小。我们目前的病例表明，免疫治疗、抗血管生成联合化疗是治疗AWT有前景的新方法。此外，我们回顾了报道AWT的文献，以增进对AWT治疗的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/8fd9fd48984d/IFSO_A_2342080_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/79c3e76a4dcd/IFSO_A_2342080_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/a041acc02baf/IFSO_A_2342080_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/8fd9fd48984d/IFSO_A_2342080_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/79c3e76a4dcd/IFSO_A_2342080_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/a041acc02baf/IFSO_A_2342080_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e54/11137782/8fd9fd48984d/IFSO_A_2342080_F0003_C.jpg

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2
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J Gynecol Oncol. 2023 Jul;34(4):e44. doi: 10.3802/jgo.2023.34.e44. Epub 2023 Feb 6.
3
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J Immunother Cancer. 2022 Jan;10(1). doi: 10.1136/jitc-2021-003497.
4
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.通过联合靶向血管生成和PD-1/PD-L1通路增强抗癌免疫力：挑战与机遇
Front Immunol. 2020 Nov 5;11:598877. doi: 10.3389/fimmu.2020.598877. eCollection 2020.
5
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Oncologist. 2021 Mar;26(3):e382-e393. doi: 10.1002/onco.13574. Epub 2020 Nov 8.
6
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