糖尿病视网膜病变患者的抗胰岛素抗体水平：一项观察性横断面研究。
Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study.
作者信息
Mohammed Bismark N, Ofori Emmanuel K, Adekena Christian N, Amponsah Seth K, Asare-Anane Henry, Amanquah Seth D, Abdul-Rahman Mubarak, Amissah-Arthur Kwesi N
机构信息
Department of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
University of Ghana Medical Center, Accra, Ghana.
出版信息
Future Sci OA. 2024 May 15;10(1):FSO982. doi: 10.2144/fsoa-2024-0002. eCollection 2024.
This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. An observational cross-sectional study. A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5-560), DM-only = 50 (5-500), versus control = 200 (7-565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.
本研究评估了糖尿病视网膜病变（DR）患者中抗胰岛素抗体（AIA）水平以及某些抗糖尿病药物对AIA的影响。这是一项观察性横断面研究。与对照组相比，在糖尿病视网膜病变（DR）组和单纯糖尿病（DM）组中观察到较低滴度的AIA IgG[DR = 86（5 - 560），单纯DM = 50（5 - 500），对照组 = 200（7 - 565）；p = 0.017]。在DR组中，服用硝苯地平和二甲双胍与AIA IgE水平呈负相关（r = -0.32，p = 0.04）。在DR组中观察到循环AIA滴度降低，这表明AIA可能与DR的发病机制无关。
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