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Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.

作者信息

XiaoMing Xu, Yan Chen, JiaMing Gu, LiTao Liang, LiJuan Zhang, Ying Song, Lu Yuan, Qian Song, Jian Dong

机构信息

Yunnan Tumor Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital/Yunnan Cellular Therapy & Quality Control System Engineering Research Center, Kunming, Yunnan, 650118, China.

Department of Obstetrics, The Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan, 650101, China.

出版信息

Future Sci OA. 2024 May 20;10(1):FSO955. doi: 10.2144/fsoa-2023-0123. eCollection 2024.

DOI:10.2144/fsoa-2023-0123
PMID:38817375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11137796/
Abstract

To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCs and hUCMSCs combined with SIS. We monitored wound healing, scores and area, and analyzed inflammatory cells, microvessel density and collagen fibers after 12 days. The blank group showed no healing, forming a scar of 0.6 × 0.5 cm, while SIS and hUCMSCs groups exhibited incomplete healing with 0.4 × 0.5 cm scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/b69793371ae2/IFSO_A_2341547_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/b89ed085d504/IFSO_A_2341547_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/08a7e1c2ef0c/IFSO_A_2341547_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/04f8dbc13b81/IFSO_A_2341547_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/86bb254da90d/IFSO_A_2341547_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/bec3341ab9c7/IFSO_A_2341547_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/47aa37ca7dd7/IFSO_A_2341547_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/b69793371ae2/IFSO_A_2341547_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/b89ed085d504/IFSO_A_2341547_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/08a7e1c2ef0c/IFSO_A_2341547_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/04f8dbc13b81/IFSO_A_2341547_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/86bb254da90d/IFSO_A_2341547_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/bec3341ab9c7/IFSO_A_2341547_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/47aa37ca7dd7/IFSO_A_2341547_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778e/11137796/b69793371ae2/IFSO_A_2341547_F0007_C.jpg

相似文献

[1]
Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.

Future Sci OA. 2024-5-20

[2]
[Effects of gelatin methacrylate anhydride hydrogel loaded with small extracellular vesicles derived from human umbilical cord mesenchymal stem cells in the treatment of full-thickness skin defect wounds in mice].

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2024-4-20

[3]
Umbilical Cord Mesenchymal Stem Cells Seeded on Small Intestinal Submucosa to Repair the Uterine Wall Injuries.

Tissue Eng Part C Methods. 2022-11

[4]
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition.

Int J Mol Sci. 2022-9-9

[5]
Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats.

Biomater Adv. 2022-5

[6]
[An experimental study of using porcine small intestinal submucosa to repair rat full skin defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007-8

[7]
Human umbilical cord blood-derived mesenchymal stromal cells and small intestinal submucosa hydrogel composite promotes combined radiation-wound healing of mice.

Cytotherapy. 2017-9

[8]
Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing.

Burns Trauma. 2021-11-30

[9]
[EXPERIMENTAL STUDY ON HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS-ALGINATE WOUND DRESSING].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015-9

[10]
Microencapsulated VEGF gene-modified umbilical cord mesenchymal stromal cells promote the vascularization of tissue-engineered dermis: an experimental study.

Cytotherapy. 2014-2

本文引用的文献

[1]
Emerging 3D bioprinting applications in plastic surgery.

Biomater Res. 2023-1-3

[2]
Secretome from human adipose-derived mesenchymal stem cells promotes blood vessel formation and pericyte coverage in experimental skin repair.

PLoS One. 2022

[3]
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine.

Biomaterials. 2022-10

[4]
Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn wound.

Regen Ther. 2022-8-23

[5]
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements.

Cells. 2022-8-6

[6]
Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products.

J Tissue Eng. 2022-7-28

[7]
Research progress of natural tissue-derived hydrogels for tissue repair and reconstruction.

Int J Biol Macromol. 2022-8-1

[8]
Histological Profiling of the Human Umbilical Cord: A Potential Alternative Cell Source in Tissue Engineering.

J Pers Med. 2022-4-18

[9]
Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice.

Int J Environ Res Public Health. 2022-1-25

[10]
Functional extracellular matrix hydrogel modified with MSC-derived small extracellular vesicles for chronic wound healing.

Cell Prolif. 2022-4

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