Raja P, Mallika K Sorna, Viva V Yuvachandran, Parthiban M, Sathish G, Vinitha V, Parthiban S, Raj G Dhinakar
Department of Animal Biotechnology, Faculty of Basic Sciences, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, 600007 India.
Virusdisease. 2024 Mar;35(1):34-40. doi: 10.1007/s13337-023-00854-7. Epub 2023 Dec 19.
Parvoviruses are ubiquitous pathogens that cause fatal disease in cats. Feline panleukopenia virus (FPV) is a primitive virus reported first and canine parvovirus (CPV) evolved from FPV and was reported later. Both induce disease in cats and dogs with correlative signs. FPV in domestic cats is genetically diverse and some strains may differ from those used for vaccination. In this study, a virus of FPV strain, ABT/MVC/2022/FPV/001, was identified from a fecal sample of the suspected cat with severe haemorrhagic gastroenteritis. The phylogenetic analysis and complete genome sequence of the strain share 99.75% nucleotide identity with FPV variant MH559110 belonging to Tamil Nadu, India. The results also reveal similarities to strains isolated from Italy, Belgium, and China. The deduced amino acid sequence of isolated strain revealed specific amino acid substitution (Pro5Ala, Phe6Val, His7Gln, Asn9Asp, Lys16Arg, Lys19Arg, Asn52Lys, Gly58Trp, Thr66Ser, Lys67Arg, Leu70His, Asn373Asp and Ala390Thr) which differed from MH559110 and other strains. The complete genomic analysis revealed that the FPV strain circulating in India is evolving rapidly with unique antigenic variations between field FPV, CPV and vaccine strains which may be the major cause for vaccine failure in vaccinated cats.
The online version contains supplementary material available at 10.1007/s13337-023-00854-7.
细小病毒是普遍存在的病原体，可导致猫患致命疾病。猫泛白细胞减少症病毒（FPV）是最早报道的一种原始病毒，犬细小病毒（CPV）由FPV进化而来，后来被报道。两者都会在猫和狗身上引发具有相关症状的疾病。家猫中的FPV在基因上具有多样性，一些毒株可能与用于疫苗接种的毒株不同。在本研究中，从一只疑似患有严重出血性肠胃炎的猫的粪便样本中鉴定出一株FPV毒株ABT/MVC/2022/FPV/001。该毒株的系统发育分析和完整基因组序列与属于印度泰米尔纳德邦的FPV变体MH559110具有99.75%的核苷酸同一性。结果还显示与从意大利、比利时和中国分离的毒株有相似之处。分离毒株的推导氨基酸序列显示出特定的氨基酸取代（Pro5Ala、Phe6Val、His7Gln、Asn9Asp、Lys16Arg、Lys19Arg、Asn52Lys、Gly58Trp、Thr66Ser、Lys67Arg、Leu70His、Asn373Asp和Ala390Thr），这与MH559110和其他毒株不同。完整的基因组分析表明，在印度流行的FPV毒株正在迅速进化，在野外FPV、CPV和疫苗毒株之间存在独特的抗原变异，这可能是接种疫苗的猫中疫苗失败的主要原因。
在线版本包含可在10.1007/s13337-023-00854-7获取的补充材料。
