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一例未确诊的纤维板层癌男孩病例,因膈肌严重出血死亡。

A Case of a Boy With Undiagnosed Fibrolamellar Carcinoma Who Died Due to Severe Hemorrhage From Diaphragm.

作者信息

Naito Haruaki, Chang Yuki, Nitta Katsuya, Kadota Eiji, Kakiuchi Yasuhiro

机构信息

Department of Forensic Medicine, Kindai University, Osakasayama, JPN.

出版信息

Cureus. 2024 Apr 30;16(4):e59355. doi: 10.7759/cureus.59355. eCollection 2024 Apr.

Abstract

An 11-year-old boy presented with vomiting and abdominal pain. Ultrasonography and blood tests revealed no abnormalities. He was diagnosed with viral gastroenteritis; however, the following morning, he was found dead in bed. Postmortem examination revealed that a 1,900 mL hemorrhage with strong coagulation from the diaphragm was the cause of death. He had no traumatic episodes, injuries, or a medical history of hemorrhagic diathesis. The presence of a fibrin-like clot indicated coagulation activation; however, most criteria for disseminated intravascular coagulation were not observed. Fibrolamellar carcinoma, a rare hepatocellular carcinoma, was found; however, liver disorder was not estimated based on the pathological findings. In conclusion, the mechanism of hemorrhage could not be explained. Although we were unable to identify the cause of the hemorrhage, we could not completely rule out the possibility that fibrolamellar carcinoma had an unknown influence on the hemorrhage. Given the limited number of studies on fibrolamellar carcinoma, we present a case of a boy with undiagnosed fibrolamellar carcinoma who died due to severe hemorrhage.

摘要

一名11岁男孩出现呕吐和腹痛症状。超声检查和血液检查均未发现异常。他被诊断为病毒性肠胃炎;然而,第二天早上,他被发现死在床上。尸检显示,横膈膜处有1900毫升伴有强烈凝血的出血是死因。他没有外伤史、受伤情况或出血素质的病史。纤维蛋白样凝块的存在表明有凝血激活;然而,并未观察到弥散性血管内凝血的大多数标准。发现了纤维板层癌,这是一种罕见的肝细胞癌;然而,根据病理结果无法评估肝脏病变情况。总之,出血机制无法解释。尽管我们无法确定出血原因,但我们不能完全排除纤维板层癌对出血有未知影响的可能性。鉴于关于纤维板层癌的研究数量有限,我们报告一例未被诊断出纤维板层癌的男孩因严重出血死亡的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db98/11138234/72a9758c2d25/cureus-0016-00000059355-i01.jpg

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