Vital Marius, Heinrich-Sanchez Ylenia
Hannover Medical School Institute for Medical Microbiology and Hospital Epidemiology Hannover Germany.
mLife. 2023 Sep 13;2(3):267-271. doi: 10.1002/mlf2.12079. eCollection 2023 Sep.
Gut microbiota-derived trimethylamine (TMA) is associated with cardiometabolic disorders and exemplifies a microbial involvement in the etiology of emerging, noncommunicable diseases, the leading causes of death worldwide. Three biochemical pathways taking dietary compounds as intake have been described with distinct taxa involved that are all present at low relative abundances. A recently discovered pathway is now considered to be the main route for TMA synthesis from l-carnitine involving γ-butyrobetaine as an intermediate product. By comprehensive (meta) genomic screening of publicly available data, namely, genomes of the UHGG catalog ( > 200,000) and 10 metagenomic (transcriptomic) data sets, we revealed bacteria synthesizing TMA via this pathway and specified their ecophysiology. Results will contribute to stratification of individuals based on their gut microbiota's potential to synthesize TMA and might aid in the development of strategies restricting TMA formation.
肠道微生物群衍生的三甲胺（TMA）与心脏代谢紊乱有关，是微生物参与全球主要死因——新出现的非传染性疾病病因的一个例证。已经描述了三条以膳食化合物为摄入物的生化途径，涉及不同的分类群，它们的相对丰度都很低。最近发现的一条途径现在被认为是从左旋肉碱合成TMA的主要途径，γ-丁基甜菜碱是其中间产物。通过对公开数据进行全面的（宏）基因组筛选，即UHGG目录（>200,000）的基因组和10个宏基因组（转录组）数据集，我们揭示了通过该途径合成TMA的细菌，并明确了它们的生态生理学特征。研究结果将有助于根据个体肠道微生物群合成TMA的潜力进行分层，并可能有助于制定限制TMA形成的策略。
