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Global research trends in immunotherapy for non-small cell lung cancer patients with KRAS mutations: a bibliometric analysis.

作者信息

Shen Hanyu, Li Chunxiao

机构信息

Department of Clinical Laboratory, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, Wuxi, Jiangsu, China.

Department of Surgery, Wuxi Huishan No.2 People's Hospital, Wuxi, Jiangsu, China.

出版信息

Front Oncol. 2024 May 16;14:1385761. doi: 10.3389/fonc.2024.1385761. eCollection 2024.


DOI:10.3389/fonc.2024.1385761
PMID:38817907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11137258/
Abstract

BACKGROUND: Immunotherapy, frequently combined with conventional chemotherapy, is crucial for treating NSCLC. Kirsten rat sarcoma virus (KRAS) is a poor prognostic factor in patients with NSCLC, particularly lung adenocarcinoma, where binding of conventional inhibitors to mutated KRAS proteins is challenging. Field profiles, research hotspots, and prospects for immunotherapy for patients with NSCLC-carrying KRAS mutations were uncovered in this study. METHODS: Microsoft Excel 2019, Bibliometrix, VOSviewer software, and Citespace were utilized to conduct a comprehensive scientometric analysis and understand a specific research field's knowledge base and frontiers aided by bibliometrics. RESULTS: Between 2014 and 2023, 398 eligible documents in the English language were acquired using the WoSCC database, of which 113 and 285 were reviews and articles, respectively. The growth rate per year was 34.25 %. The most cited articles were from the United States, and China published the highest number of articles. Cancers was the journal, with increased publications in recent years. The keywords with the strongest citation bursts were analyzed using Citespace. "Immune checkpoint inhibitors," "co-occurring genomic alterations," and "KRAS" are among the research hotspots in this field. CONCLUSION: Using bibliometric and visual analyses, we examined immunotherapy for patients with KRAS-mutant NSCLC over the previous decade. The whole analysis showed a steady, quick increase in yearly publications in this area. Our findings will provide a roadmap for future research on the mechanisms of immunotherapy and immune checkpoint inhibitor action in treating KRAS-mutant NSCLC.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/e1641c8c7b31/fonc-14-1385761-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/4baef9e55e08/fonc-14-1385761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/df86a392bfcd/fonc-14-1385761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/3803ed38f82d/fonc-14-1385761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/fb40222467cb/fonc-14-1385761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/03e32c22fe4d/fonc-14-1385761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/76de7d810966/fonc-14-1385761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/68eb1d091d21/fonc-14-1385761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/e1641c8c7b31/fonc-14-1385761-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/4baef9e55e08/fonc-14-1385761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/df86a392bfcd/fonc-14-1385761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/3803ed38f82d/fonc-14-1385761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/fb40222467cb/fonc-14-1385761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/03e32c22fe4d/fonc-14-1385761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/76de7d810966/fonc-14-1385761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/68eb1d091d21/fonc-14-1385761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7e/11137258/e1641c8c7b31/fonc-14-1385761-g008.jpg

相似文献

[1]
Global research trends in immunotherapy for non-small cell lung cancer patients with KRAS mutations: a bibliometric analysis.

Front Oncol. 2024-5-16

[2]
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Eur J Med Res. 2023-7-10

[3]
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[4]
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Front Oncol. 2023-5-31

[5]
The research advances in Kirsten rat sarcoma viral oncogene homolog (KRAS)-related cancer during 2013 to 2022: a scientometric analysis.

Front Oncol. 2024-4-19

[6]
Immune-related adverse events: A bibliometric analysis.

Front Immunol. 2022

[7]
Knowledge mapping of immunotherapy in cervical carcinoma: a bibliometric analysis (2000-2023).

Front Immunol. 2023

[8]
Knowledge structure and hotspots research of glioma immunotherapy: a bibliometric analysis.

Front Oncol. 2023-8-21

[9]
Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study.

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[10]
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本文引用的文献

[1]
Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study.

Front Oncol. 2024-3-4

[2]
Clinicopathologic features, concurrent genomic alterations, and clinical outcomes of patients with KRAS G12D mutations in resected lung adenocarcinoma.

Eur J Cancer. 2024-5

[3]
A bibliometric analysis of macrophages associated with non-alcoholic fatty liver disease research from 2005 to 2023.

Heliyon. 2024-1-7

[4]
Plunging Into the PACIFIC: Outcomes of Patients With Unresectable KRAS-Mutated Non-Small Cell Lung Cancer Following Definitive Chemoradiation and Durvalumab Consolidation.

Clin Lung Cancer. 2024-5

[5]
Outcome of First-Line Treatment With Pembrolizumab According to KRAS/TP53 Mutational Status for Nonsquamous Programmed Death-Ligand 1-High (≥50%) NSCLC in the German National Network Genomic Medicine Lung Cancer.

J Thorac Oncol. 2024-5

[6]
A novel long noncoding RNA (lncRNA), LINC02657(LASTR), is a prognostic biomarker associated with immune infiltrates of lung adenocarcinoma based on unsupervised cluster analysis.

PeerJ. 2023

[7]
Evaluating distinct KRAS subtypes as potential biomarkers for immune checkpoint inhibitor efficacy in lung adenocarcinoma.

Front Immunol. 2023

[8]
The current landscape of using direct inhibitors to target KRAS-mutated NSCLC.

Exp Hematol Oncol. 2023-11-4

[9]
KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells.

Cancer Cell. 2023-9-11

[10]
Outcomes of Combination Platinum-Doublet Chemotherapy and Anti-PD(L)-1 Blockade in KRASG12C-Mutant Non-Small Cell Lung Cancer.

Oncologist. 2023-11-2

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