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单分子片段偶联：一种通过原子消除形成新键的方法。

Unimolecular Fragment Coupling: A New Bond-Forming Methodology via the Deletion of Atom(s).

作者信息

Shimazumi Ryoma, Tobisu Mamoru

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University, Suita, Osaka 565-0871, Japan.

出版信息

JACS Au. 2024 Apr 23;4(5):1676-1695. doi: 10.1021/jacsau.3c00827. eCollection 2024 May 27.

DOI:10.1021/jacsau.3c00827
PMID:38818052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11134393/
Abstract

Unimolecular fragment coupling (UFC) is defined as a reaction format, wherein atom(s) located in the middle of a molecule are extruded, and the remaining fragments are coupled. UFC is a potentially powerful strategy that is an alternative to transition-metal-catalyzed cross-coupling because the target chemical bond is formed in an intramolecular fashion, which is inherently beneficial for chemoselectivity and stereoselectivity issues. In this Perspective, we will present an overview of the recent advances in UFC reactions, which encompass those proceeding through the elimination of CO, CO, SO, isocyanates, N, or single atoms primarily via transition metal catalysis.

摘要

单分子片段偶联（UFC）被定义为一种反应形式，其中位于分子中间的原子被挤出，其余片段进行偶联。UFC是一种潜在的强大策略，可作为过渡金属催化交叉偶联的替代方法，因为目标化学键以分子内方式形成，这本质上有利于化学选择性和立体选择性问题。在本综述中，我们将概述UFC反应的最新进展，这些进展包括主要通过过渡金属催化消除CO、CO、SO、异氰酸酯、N或单个原子的反应。

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