Xu Li, Fan Yu-Hong, Zhang Xiao-Jing, Bai Lan
State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou 341000, China.
School of Basic Medical Sciences, Wuhan University, Wuhan 430060, China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou 341000, China.
World J Hepatol. 2024 May 27;16(5):703-715. doi: 10.4254/wjh.v16.i5.703.
Non-alcoholic fatty liver disease (NAFLD) poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits. Its complexity stems from genetic predisposition, environmental influences, and metabolic factors. Epigenetic processes govern various cellular functions such as transcription, chromatin structure, and cell division. In NAFLD, these epigenetic tendencies, especially the process of histone methylation, are intricately intertwined with fat accumulation in the liver. Histone methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to adipogenesis. While early-stage NAFLD is reversible, its progression to severe stages becomes almost irreversible. Therefore, early detection and intervention in NAFLD are crucial, and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.
由于生活方式和饮食习惯的改变，非酒精性脂肪性肝病（NAFLD）在现代社会中构成了重大的健康挑战。其复杂性源于遗传易感性、环境影响和代谢因素。表观遗传过程调控着各种细胞功能，如转录、染色质结构和细胞分裂。在NAFLD中，这些表观遗传倾向，尤其是组蛋白甲基化过程，与肝脏中的脂肪堆积错综复杂地交织在一起。组蛋白甲基化由甲基转移酶和去甲基酶等不同酶调控，并影响与脂肪生成相关基因的表达。虽然NAFLD早期阶段是可逆的，但其进展到严重阶段几乎不可逆转。因此，NAFLD的早期检测和干预至关重要，了解组蛋白甲基化在NAFLD早期的确切作用对于阻止或潜在逆转该疾病的进展可能至关重要。
