Bazie Michee M, Sanou Mahamoudou, Djigma Florencia Wendkuuni, Compaore Tegwinde Rebeca, Obiri-Yeboah Dorcas, Kabamba Benoît, Nagalo Bolni Marius, Simpore Jacques, Ouédraogo Rasmata
Department of Medicine, Transmissible Diseases Laboratory, Université Joseph KI-ZERBO, Ouagadougou 0000, Burkina Faso.
Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory, University Joseph KI-ZERBO, Ouagadougou 0000, Burkina Faso.
World J Hepatol. 2024 May 27;16(5):843-859. doi: 10.4254/wjh.v16.i5.843.
Occult hepatitis B infection (OBI) is a globally prevalent infection, with its frequency being influenced by the prevalence of hepatitis B virus (HBV) infection in a particular geographic region, including Africa. OBI can be transmitted through blood transfusions and organ transplants and has been linked to the development of hepatocellular carcinoma (HCC). The associated HBV genotype influences the infection.
To highlight the genetic diversity and prevalence of OBI in Africa.
This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and involved a comprehensive search on PubMed, Google Scholar, Science Direct, and African Journals Online for published studies on the prevalence and genetic diversity of OBI in Africa.
The synthesis included 83 articles, revealing that the prevalence of OBI varied between countries and population groups, with the highest prevalence being 90.9% in patients with hepatitis C virus infection and 38% in blood donors, indicating an increased risk of HBV transmission through blood transfusions. Cases of OBI reactivation have been reported following chemotherapy. Genotype D is the predominant, followed by genotypes A and E.
This review highlights the prevalence of OBI in Africa, which varies across countries and population groups. The study also demonstrates that genotype D is the most prevalent.
隐匿性乙型肝炎病毒感染（OBI）是一种全球流行的感染，其感染率受特定地理区域（包括非洲）乙型肝炎病毒（HBV）感染率的影响。OBI可通过输血和器官移植传播，并与肝细胞癌（HCC）的发生有关。相关的HBV基因型会影响感染情况。
强调非洲OBI的遗传多样性和感染率。
本系统评价遵循系统评价和Meta分析的首选报告项目指南，全面检索了PubMed、谷歌学术、科学Direct和非洲在线期刊，以查找有关非洲OBI感染率和遗传多样性的已发表研究。
综合纳入83篇文章，结果显示OBI的感染率在不同国家和人群中有所不同，丙型肝炎病毒感染患者中的最高感染率为90.9%，献血者中的感染率为38%，这表明通过输血传播HBV的风险增加。化疗后有OBI再激活的病例报告。D基因型最为常见，其次是A和E基因型。
本综述强调了非洲OBI的感染率，其在不同国家和人群中存在差异。该研究还表明D基因型最为普遍。
