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潜在的标志物以区分子宫平滑肌肉瘤与平滑肌瘤。

Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas.

机构信息

Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310003 Hangzhou, Zhejiang Province, China.

Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, 350014 Fuzhou, Fujian Province, China.

出版信息

Int J Med Sci. 2024 May 13;21(7):1227-1240. doi: 10.7150/ijms.93464. eCollection 2024.

DOI:10.7150/ijms.93464
PMID:38818470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11134592/
Abstract

Uterine leiomyomas (ULM) are the most common benign tumors of the female genitalia, while uterine leiomyosarcomas (ULMS) are rare. The sarcoma is diffuse growth, prone to hematogenous metastasis, and has a poor prognosis. Due to their similar clinical symptoms and morphological features, it is sometimes difficult to distinguish them, and the final diagnosis depends on histological diagnosis. Misdiagnosis of ULM as ULMS will lead to more invasive and extensive surgery when it is not needed, while misdiagnosis of ULMS as ULM may lead to delayed treatment and poor prognosis. This review searched and studied the published articles on ULM and ULMS, and summarized the potential markers for the differential diagnosis of ULMS. These markers will facilitate differential diagnosis and personalized treatment, providing timely diagnosis and potentially better prognosis for patients.

摘要

子宫肌瘤（ULM）是女性生殖器官最常见的良性肿瘤，而子宫平滑肌肉瘤（ULMS）则较为罕见。肉瘤呈弥漫性生长，易发生血行转移，预后不良。由于它们具有相似的临床症状和形态特征，有时难以区分，最终诊断依赖于组织学诊断。将 ULM 误诊为 ULMS 时，在不需要的情况下会导致更具侵袭性和广泛性的手术，而将 ULMS 误诊为 ULM 可能会导致治疗延误和预后不良。本综述对已发表的关于 ULM 和 ULMS 的文章进行了检索和研究，总结了用于鉴别诊断 ULMS 的潜在标志物。这些标志物将有助于鉴别诊断和个体化治疗，为患者提供及时的诊断和潜在更好的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/a8bd438947ab/ijmsv21p1227g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/c7a38ba339c7/ijmsv21p1227g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/401b3c56dada/ijmsv21p1227g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/2cb3c70dfcb7/ijmsv21p1227g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/7e55f9b9c229/ijmsv21p1227g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/7beae6a2b222/ijmsv21p1227g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/a8bd438947ab/ijmsv21p1227g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/c7a38ba339c7/ijmsv21p1227g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/401b3c56dada/ijmsv21p1227g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/2cb3c70dfcb7/ijmsv21p1227g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/7e55f9b9c229/ijmsv21p1227g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/7beae6a2b222/ijmsv21p1227g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bcb/11134592/a8bd438947ab/ijmsv21p1227g006.jpg

相似文献

[1]
Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas.

Int J Med Sci. 2024

[2]
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[3]
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[4]
Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma.

Exp Mol Pathol. 2019-7-10

[5]
The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.

Am J Obstet Gynecol. 2019-5-20

[6]
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Pathol Oncol Res. 2010-9-18

[7]
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas.

Int J Clin Exp Pathol. 2015-3-1

[8]
Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy.

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[9]
Validating the diagnostic accuracy of an MRI-based scoring system for differentiating benign uterine leiomyomas from leiomyosarcomas.

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[10]
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant.

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引用本文的文献

[1]
A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors.

Front Oncol. 2025-8-4

[2]
Integrated analysis of uterine leiomyosarcoma and leiomyoma utilizing TCGA and GEO data: a WGCNA and machine learning approach.

Transl Cancer Res. 2025-5-30

[3]
Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy.

Cells. 2024-6-26

本文引用的文献

[1]
LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions.

J Transl Med. 2023-3-28

[2]
TEM1 up-regulates MMP-2 and promotes ECM remodeling for facilitating invasion and migration of uterine sarcoma.

Discov Oncol. 2023-1-13

[3]
DPP6 and MFAP5 are associated with immune infiltration as diagnostic biomarkers in distinguishing uterine leiomyosarcoma from leiomyoma.

Front Oncol. 2022-11-30

[4]
Uterine leiomyoma as useful model to unveil morphometric and macromolecular collagen state and impairment in fibrotic diseases: An ex-vivo human study.

Biochim Biophys Acta Mol Basis Dis. 2022-12-1

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Ultrasound-Guided Trans-Uterine Cavity Core Needle Biopsy of Uterine Myometrial Tumors to Differentiate Sarcoma from a Benign Lesion-Description of the Method and Review of the Literature.

Diagnostics (Basel). 2022-5-29

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Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma.

Int J Mol Sci. 2022-2-16

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Chemotherapy-Induced Changes in the Lung Microenvironment: The Role of MMP-2 in Facilitating Intravascular Arrest of Breast Cancer Cells.

Int J Mol Sci. 2021-9-24

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Diagnostics (Basel). 2021-7-2

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World J Surg Oncol. 2021-7-28

[10]
Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells.

Cells. 2020-12-31

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