LASSO 回归和基于 WGCNA 的端粒酶相关 lncRNA 信号预测透明细胞肾细胞癌的预后和免疫治疗反应。
LASSO regression and WGCNA-based telomerase-associated lncRNA signaling predicts clear cell renal cell carcinoma prognosis and immunotherapy response.
机构信息
Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Medical Research Center, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
出版信息
Aging (Albany NY). 2024 May 30;16(11):9386-9409. doi: 10.18632/aging.205871.
OBJECTIVE
To investigate whether telomerase-associated lncRNA expression affects the prognosis and anti-tumor immunity of patients with renal clear cell carcinoma (ccRCC).
METHODS
A series of analyses were performed to establish a prognostic risk model and validate its accuracy. Immune-related analyses were performed to assess further the association between immune status, tumor microenvironment, and prognostic risk models.
RESULTS
Eight telomerase-associated lncRNAs associated with prognosis were identified and applied to establish a prognostic risk model. Overall survival was higher in the low-risk group.
CONCLUSION
The established prognostic risk model has a good predictive ability for the prognosis of ccRCC patients and provides a new possible therapeutic target for ccRCC.
目的
研究端粒酶相关长链非编码 RNA 表达是否影响肾透明细胞癌 (ccRCC) 患者的预后和抗肿瘤免疫。
方法
进行了一系列分析，以建立预后风险模型并验证其准确性。进行免疫相关分析，以进一步评估免疫状态、肿瘤微环境与预后风险模型之间的关系。
结果
确定了 8 个与预后相关的端粒酶相关长链非编码 RNA，并将其应用于建立预后风险模型。低危组的总生存率更高。
结论
所建立的预后风险模型对 ccRCC 患者的预后具有良好的预测能力，并为 ccRCC 提供了一个新的潜在治疗靶点。
Zotero 插件