[大肠杆菌苯丙氨酰 - tRNA合成酶与tRNA Phe复合物的化学修饰]
[Chemical modification of the complex of tRNA Phe with phenylalanyl-tRNA synthetase from Escherichia coli].
作者信息
Ankilova V N, Vlasov V V, Mamaev S V, Nuzhdina N A
出版信息
Mol Biol (Mosk). 1979 Sep-Oct;13(5):994-1000.
PMID:388193
Abstract
Alkylation of E. coli tRNAPhe, bound to the cognate synthetase was investigated. The alkylating reagent is a derivative of 2-chloroethylamine: 2',3'-O-[4(N-2-chloroethyl-N-methylamino)-benzylidene]-uridine-5'-methylphosphate. It was found that the enzyme protects from the reaction D-stem (guanosine G24) and the region of juxtaposition of acceptor stem and D-stem (S4U8 and C13) in the tRNAPhe.
摘要
对与同源合成酶结合的大肠杆菌苯丙氨酸转运核糖核酸（tRNAPhe）的烷基化进行了研究。烷基化试剂是2-氯乙胺的衍生物：2',3'-O-[4（N-2-氯乙基-N-甲基氨基）-亚苄基]-尿苷-5'-甲基磷酸酯。研究发现，该酶可保护tRNAPhe中的D茎（鸟苷G24）以及受体茎与D茎并列的区域（S4U8和C13）免受反应影响。
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