Barrera Gladys, Bunout Daniel, Gattás Vivien, de la Maza María Pía, Leiva Laura, Hirsch Sandra
Institute of Nutrition and Food Technology, University of Chile, Santiago.
Nutrition. 2004 Sep;20(9):769-71. doi: 10.1016/j.nut.2004.05.014.
In a large sample of elderly subjects, we assessed the possible protective effect of obesity on the development of osteoporosis.
Healthy subjects 70 y or older and of low socioeconomic level were studied. Bone mineral density was measured in the femoral neck by using a Lunar Prodigy double beam densitometer and compared measurements with appropriate standards. Osteoporosis was defined according to criteria of the World Health Organization (WHO). Body weight and height were recorded simultaneously, and body mass index (BMI) was calculated as weight (kg) divided by height (m2). Age-adjusted odds ratios for femoral osteoporosis were calculated for WHO-proposed BMI ranges in women and men, with an odds of one for a BMI below 25 kg/m2.
Eight hundred forty-five subjects (615 women and 230 men; mean age, 75 +/- 4.4 y) were studied. Mean BMI was 28.1 +/- 4.7 kg/m2. Twenty five percent of women and 11% of men had osteoporosis (P < 0.001). Forward stepwise multiple regression analysis showed BMI to be the best independent predictor of bone mineral density in women and men. The age-adjusted odds ratios for femoral osteoporosis were 0.34 (95% confidence interval [CI], 0.21 to 0.55) and 0.13 (95% CI, 0.04 to 0.43) for women and men with a BMI between 25 and 30 kg/m2, respectively. The odds ratios for women and men with a BMI between 30 and 35 kg/m2 were 0.21 (95% CI, 0.11 to 0.39) and 0.09 (95% CI, 0.01 to 0.67), respectively
This study confirms the protective effect of a high BMI on femoral neck bone mineral density among elderly subjects. The risk for osteoporosis among men and women with a BMI above 30 kg/m2 was approximately 33% compared with subjects with a normal BMI.
在大量老年受试者样本中，我们评估了肥胖对骨质疏松症发生可能的保护作用。
对70岁及以上且社会经济水平较低的健康受试者进行研究。使用Lunar Prodigy双能X线骨密度仪测量股骨颈骨密度，并将测量结果与适当标准进行比较。根据世界卫生组织（WHO）的标准定义骨质疏松症。同时记录体重和身高，并计算体重指数（BMI），即体重（千克）除以身高（米的平方）。针对WHO提出的女性和男性BMI范围，计算年龄调整后的股骨骨质疏松症比值比，BMI低于25kg/m²时比值为1。
共研究了845名受试者（615名女性和230名男性；平均年龄75±4.4岁）。平均BMI为28.1±4.7kg/m²。25%的女性和11%的男性患有骨质疏松症（P<0.001）。向前逐步多元回归分析显示，BMI是女性和男性骨密度的最佳独立预测因子。BMI在25至30kg/m²之间的女性和男性，年龄调整后的股骨骨质疏松症比值比分别为0.34（95%置信区间[CI]，0.21至0.55）和0.13（95%CI，0.04至0.43）。BMI在30至35kg/m²之间的女性和男性的比值比分别为0.21（95%CI，0.11至0.39）和0.09（95%CI，0.01至0.67）。
本研究证实了高BMI对老年受试者股骨颈骨密度的保护作用。与BMI正常的受试者相比，BMI高于30kg/m²的男性和女性患骨质疏松症的风险约为33%。
