Aikawa M, Rabbege J, Uni S, Ristic M, Miller L H
Am J Trop Med Hyg. 1985 Jan;34(1):45-9. doi: 10.4269/ajtmh.1985.34.45.
Babesia bovis, causative agent of cattle babesiosis, induces characteristic alterations on the membrane of infected erythrocytes. Elliptical protrusions measuring about 320 nm in long axis and about 160 nm in short axis appear on the membrane of infected erythrocytes, both in vitro and in vivo. Freeze-fracture demonstrated alignment of intramembrane particles (IMP) along the long axis of both the P and E faces of the protrusions. The number of IMP on the endoplasmic face increases, but the number of IMP on the protoplasmic face of the protrusions is not statistically altered from that of uninfected erythrocytes. In vitro, there are more protrusions per erythrocyte infected with the virulent form (low passage form) of B. bovis than with the avirulent form (high passage form). This suggests that the number of protrusions which appear on the membrane of infected erythrocytes may have a direct relationship to the virulence of the parasites. These protrusions may be attached to the capillary endothelial cells, which causes fatal cerebral babesiosis.
牛巴贝斯虫是牛巴贝斯虫病的病原体，可引起受感染红细胞膜的特征性改变。在体外和体内，受感染红细胞膜上都会出现长轴约320纳米、短轴约160纳米的椭圆形突起。冷冻蚀刻显示，膜内颗粒（IMP）沿突起的P面和E面的长轴排列。内质面上IMP的数量增加，但突起原生质面上IMP的数量与未感染红细胞相比无统计学差异。在体外，感染牛巴贝斯虫强毒株（低传代形式）的每个红细胞上的突起比感染无毒株（高传代形式）的更多。这表明出现在受感染红细胞膜上的突起数量可能与寄生虫的毒力有直接关系。这些突起可能附着在毛细血管内皮细胞上，从而导致致命的脑巴贝斯虫病。
