Schmidt H, Bafort J M
Am J Trop Med Hyg. 1985 Jan;34(1):64-8. doi: 10.4269/ajtmh.1985.34.64.
Histological sections of the brain from Microtus montanus infected with Trypanosoma rhodesiense and treated after the initial infection period showed that trypanosomes promptly invade the brain tissue and induce a severe encephalitis within a very short time. These findings suggest that the brain invasion and encephalitis that occur after treatment in sleeping sickness must be considered an effect of the treatment. The results illustrate that the brain invasion is probably not hematogenic but rather due to a process of parasite migration from the subarachnoidal space over the Virchow-Robin spaces into the brain.
对感染罗德西亚锥虫的蒙塔努斯田鼠在初始感染期后进行治疗，其脑组织的组织学切片显示，锥虫迅速侵入脑组织，并在极短时间内引发严重脑炎。这些发现表明，昏睡病治疗后发生的脑部侵袭和脑炎必须被视为治疗的一种效应。结果表明，脑部侵袭可能不是血源性的，而是由于寄生虫从蛛网膜下腔通过维氏-罗宾间隙迁移到大脑的过程所致。
