GSK, Cambridge, MA, USA.
GSK, Siena, Italy.
Carbohydr Res. 2024 Jul;541:109165. doi: 10.1016/j.carres.2024.109165. Epub 2024 May 25.
Streptococcus pneumoniae is one of the globally important encapsulated human pathogens and more than 100 different serotypes have been identified. Despite very extensive genetic and immune-serological studies, the capsular polysaccharide repeating unit structure of several serotypes has not been determined yet, including the type 38 (type 38 in Danish nomenclature; type 71 in US nomenclature). Physicochemical data revealed that type 38 polysaccharide is composed of a pentasaccharide repeat unit →3)-[β-D-Galf(1 → 2)]-β-D-GalpA6(L-Ser)-(1 → 3)-α-D-GlcpNAc-(1 → 3)-α-D-Sugp-(1 → 4)-α-D-Galp(2OAc)-(1 → . The polysaccharide is O-acetylated at position C of the α-Gal residue at approximately (68-87 %) of the repeat units.
肺炎链球菌是全球重要的人源包被病原体之一，目前已鉴定出超过 100 种不同的血清型。尽管进行了非常广泛的遗传和免疫血清学研究，但仍有几种血清型的荚膜多糖重复单元结构尚未确定，包括 38 型（丹麦命名法中的 38 型；美国命名法中的 71 型）。理化数据表明，38 型多糖由五糖重复单元组成→3）-[β-D-Galf(1 → 2)]-β-D-GalpA6(L-Ser)-(1 → 3)-α-D-GlcpNAc-(1 → 3)-α-D-Sugp-(1 → 4)-α-D-Galp(2OAc)-(1 →。多糖在重复单元的α-Gal 残基的 C 位置（约 68-87%）被 O-乙酰化。
