神经欺骗：乳腺癌利用神经元机制逃避免疫系统。

Neural deception: Breast cancer co-opts neuronal mechanisms to evade the immune system.

机构信息

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.

Department of Neurology, Medical Faculty Mannheim, MCTN Heidelberg University, Mannheim, Germany; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

出版信息

Cancer Cell. 2024 Jun 10;42(6):936-938. doi: 10.1016/j.ccell.2024.05.007. Epub 2024 May 30.

DOI:10.1016/j.ccell.2024.05.007

PMID:38821062

Abstract

Cellular mechanisms mediating immunotherapy resistances are incompletely understood. In this issue, Li et al. reveal how breast cancer hijacks neuronal mechanisms of neuroprotection to shield itself from the immune system. Secretion of N-acetylaspartate impairs immune synapse formation in both neuroinflammation and breast cancer models, paving the way for novel therapeutic approaches.

摘要

细胞机制介导的免疫疗法耐药性不完全清楚。在本期杂志中，李等人揭示了乳腺癌如何劫持神经元的神经保护机制来保护自己免受免疫系统的攻击。N-乙酰天门冬氨酸的分泌会损害神经炎症和乳腺癌模型中的免疫突触形成，为新的治疗方法铺平了道路。