Boyle Sarah T, Kochetkova Marina
School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
J Mammary Gland Biol Neoplasia. 2014 Jul;19(2):203-11. doi: 10.1007/s10911-014-9323-y. Epub 2014 Jul 6.
Cancer stem cells are believed to be a subset of heterogeneous tumour cells responsible for tumour initiation, growth, local invasion, and metastasis. In breast cancer, numerous factors have been implicated in regulation of cancer stem cells, but there is still a paucity of information regarding precise molecular and cellular mechanisms guiding their pathobiology. Components of both the adaptive and the innate immune system have been shown to play a crucial role in supporting breast cancer growth and spread, and recently some immune mediators, both molecules and cells, have been reported to influence breast cancer stem cell biology. This review summarises a small, pioneering body of evidence for the potentially important function of the "immuniche" in maintaining and supporting breast cancer stem cells.
癌症干细胞被认为是异质性肿瘤细胞的一个亚群，负责肿瘤的起始、生长、局部侵袭和转移。在乳腺癌中，许多因素与癌症干细胞的调控有关，但关于指导其病理生物学的精确分子和细胞机制，仍缺乏相关信息。适应性免疫系统和先天性免疫系统的组成部分均已被证明在支持乳腺癌的生长和扩散中发挥关键作用，最近有报道称一些免疫介质，包括分子和细胞，会影响乳腺癌干细胞生物学。这篇综述总结了一小部分具有开创性的证据，证明“免疫小生境”在维持和支持乳腺癌干细胞方面可能具有重要功能。
