Department of Thoracic and Cardiovascular Surgery, Mie University Hospital, 2-174, Edobashi, Tsu, Mie, 514-8507, Japan.
Department of Radiology, Mie University Hospital, Tsu, Mie, Japan.
Gen Thorac Cardiovasc Surg. 2024 Dec;72(12):770-778. doi: 10.1007/s11748-024-02043-9. Epub 2024 May 31.
The aim of this study is to analyze long-term results of the total aortic arch replacement with the frozen elephant trunk technique for primary chronic type B aortic dissection.
Among 322 patients who had the frozen elephant trunk technique, 43 (13.4%) patients (median age, 64.0 years) with primary chronic type B aortic dissection were analyzed. The patients underwent surgery at a median of 27.0 months after the onset of aortic dissection. The false lumen was patent in 30 (69.8%) patients preoperatively.
Two patients suffered paraplegia and another died of cerebral infarction. Complete thrombosis of the peri-stent false lumen was achieved in 36 (83.7%) patients. Overall survival, freedom from aortic events, and freedom from aortic reintervention were 83.5%, 37.2%, and 42.2% at 5 years, respectively. Survival rates of the patients with or without aortic events were 75.0% and 95.8% at 5 years (Log-rank, p = 0.22). Late aortic events occurred in 19 (44.2%) patients including distal stent graft-induced new entry, type Ib endoleak, and false lumen dilation. The ratio of the stent graft diameter to the preoperative short axis diameter of the true lumen (hazard ratio, 1.90; 95% confidence interval, 1.01-3.59), and the maximal diameter of a postdissection aneurysm (1.07; 1.01-1.12) were the significant multivariate risk predictors of late aortic events.
Late aortic events occurr fairly frequently, and new strategies need to be explored to enhance the effectiveness of this procedure in the future.
本研究旨在分析应用冷冻象鼻技术行全主动脉弓置换术治疗原发性慢性 B 型主动脉夹层的长期结果。
在 322 例行冷冻象鼻技术的患者中,分析了 43 例(13.4%)原发性慢性 B 型主动脉夹层患者(中位年龄 64.0 岁)。这些患者在主动脉夹层发病后中位 27.0 个月接受手术。30 例(69.8%)患者术前假腔仍通畅。
2 例患者发生截瘫,另 1 例患者死于脑梗死。36 例(83.7%)患者支架内假腔完全血栓形成。5 年时总生存率、无主动脉事件生存率和无主动脉再次介入治疗生存率分别为 83.5%、37.2%和 42.2%。有和无主动脉事件的患者生存率分别为 75.0%和 95.8%(对数秩检验,p=0.22)。19 例(44.2%)患者发生晚期主动脉事件,包括远端支架移植物导致的新入口、Ib 型内漏和假腔扩张。支架移植物直径与术前真腔短轴直径的比值(危险比,1.90;95%置信区间,1.01-3.59)和夹层动脉瘤的最大直径(1.07;1.01-1.12)是晚期主动脉事件的显著多变量危险因素。
晚期主动脉事件相当常见,未来需要探索新策略以提高该术式的效果。