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采用带支架象鼻技术的主动脉弓置换术——一项单中心研究

Aortic arch replacement with frozen elephant trunk technique - a single-center study.

作者信息

Kremer Jamila, Preisner Fabian, Dib Bashar, Tochtermann Ursula, Ruhparwar Arjang, Karck Matthias, Farag Mina

机构信息

Department of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld, 400, Heidelberg, Germany.

出版信息

J Cardiothorac Surg. 2019 Aug 1;14(1):147. doi: 10.1186/s13019-019-0969-9.

Abstract

BACKGROUND

The frozen elephant trunk (FET) technique was developed to facilitate the two-stage surgery of extensive pathologies of the thoracic aorta and is now routinely applied in acute and chronic aortic syndromes.

METHODS

From 11/2006 to 07/2017, 68 patients underwent aortic arch repair using the FET technique. Patients received either the Jotec E-vita Open graft (n = 57) or the Vascutek Thoraflex hybrid prosthesis (n = 11). Both, group 1 (acute aortic dissection type A and B; symptomatic penetrating aortic ulcer) and group 2 (aortic aneurysm; chronic aortic dissection) included 34 patients each.

RESULTS

Early mortality was 13.2% (14.7% in group 1 vs. 11.7% in group 2, p = 0.720). Neurological complications occurred in 12 patients (17.6%) (stroke: 8.8 vs. 11.7%; p = 0.797 and spinal cord injury: 8.8 vs. 5.9%; p = 0.642 in groups 1 vs. 2 respectively). Cardiopulmonary bypass time and cross clamp time were significantly longer in group 1 (252.2 ± 73.5 and 148.3 ± 34 min vs. 189.2 ± 47.8 and 116.3 ± 34.5 min; p <  0.001). The overall 1-, 3- and 7-year-survival was 80.9, 80.9 and 74.2% with no significant differences between groups 1 and 2. Expansion of true lumen after FET implantation was significant at all levels in both groups for patients with aortic dissection. One-, 3-, and 7-year-freedom from secondary (re-)intervention for patients for aortic dissection was 96.9, 90.2 and 82.7% with no significant differences between groups 1 and 2; p = 0.575.

CONCLUSION

The FET technique can be applied in acute aortic syndromes with similar risks regarding adverse events or mortality when compared to chronic degenerative aortic disease. Postoperative increase in true lumen diameter mirrors decrease of false lumen diameter, goes along with favorable midterm outcome and prolongs freedom from secondary interventions in acute aortic dissection.

摘要

背景

冷冻象鼻技术(FET)被开发用于促进胸主动脉广泛病变的两阶段手术,目前已常规应用于急性和慢性主动脉综合征。

方法

2006年11月至2017年7月,68例患者采用FET技术进行主动脉弓修复。患者接受Jotec E-vita Open移植物(n = 57)或Vascutek Thoraflex混合假体(n = 11)。第1组(急性A型和B型主动脉夹层;有症状的穿透性主动脉溃疡)和第2组(主动脉瘤;慢性主动脉夹层)各有34例患者。

结果

早期死亡率为13.2%(第1组为14.7%,第2组为11.7%,p = 0.720)。12例患者(17.6%)发生神经系统并发症(中风:第1组为8.8%,第2组为11.7%;p = 0.797;脊髓损伤:第1组为8.8%,第2组为5.9%;p = 0.642)。第1组的体外循环时间和主动脉阻断时间明显更长(252.2±73.5分钟和148.3±34分钟,而第2组为189.2±47.8分钟和116.3±34.5分钟;p < 0.001)。总体1年、3年和7年生存率分别为80.9%、80.9%和74.2%,第1组和第2组之间无显著差异。对于主动脉夹层患者,两组在FET植入后真腔在所有层面均有显著扩大。主动脉夹层患者1年、3年和7年免于二次(再次)干预的比例分别为96.9%、90.2%和82.7%,第1组和第2组之间无显著差异;p = 0.575。

结论

与慢性退行性主动脉疾病相比,FET技术可应用于急性主动脉综合征,不良事件或死亡率风险相似。术后真腔直径增加反映假腔直径减小,伴随着良好的中期结果,并延长了急性主动脉夹层免于二次干预的时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5567/6676558/065031e038b6/13019_2019_969_Fig1_HTML.jpg

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