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揭示维生素C对术后脊柱疼痛的潜在影响。

Unveiling the potential impact of vitamin C in postoperative spinal pain.

作者信息

Ranjbari Fatemeh, Alimohammadi Ehsan

机构信息

Clinical Research Development Center Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Chin Neurosurg J. 2024 Jun 1;10(1):16. doi: 10.1186/s41016-024-00368-1.

Abstract

BACKGROUND

Spinal surgery is a common procedure associated with significant postoperative pain, and identifying effective interventions to manage this pain is crucial for optimizing patient outcomes. This review assesses the existing literature to determine the overall impact of vitamin C supplementation on spinal postoperative pain. Vitamin C, also known as ascorbic acid, is an essential nutrient that plays a vital role in numerous physiological processes. It functions as a potent antioxidant, neutralizing free radicals and reducing oxidative stress within the body. Furthermore, vitamin C is a cofactor in collagen synthesis, a crucial component of connective tissues, including those found in the spinal structures. Given its antioxidant and collagen-promoting properties, vitamin C has piqued interest as a potential therapeutic option for postoperative spinal pain. Based on the available evidence, vitamin C may have a beneficial effect on postoperative spinal pain, including reducing pain scores, analgesic consumption, and the incidence of complications such as complex regional pain syndrome. However, more research is needed to fully understand the optimal dosage and duration of vitamin C supplementation for postoperative pain management.

CONCLUSION

Vitamin C could be considered a potentially beneficial adjunctive therapy for managing spinal postoperative pain, but its routine use requires further investigation.

摘要

背景

脊柱手术是一种常见的手术,术后疼痛较为明显,确定有效的疼痛管理干预措施对于优化患者预后至关重要。本综述评估现有文献,以确定补充维生素C对脊柱术后疼痛的总体影响。维生素C,又称抗坏血酸,是一种必需营养素,在众多生理过程中发挥着至关重要的作用。它作为一种强大的抗氧化剂,中和自由基并减少体内的氧化应激。此外,维生素C是胶原蛋白合成的辅助因子,胶原蛋白是结缔组织的关键成分,包括脊柱结构中的结缔组织。鉴于其抗氧化和促进胶原蛋白生成的特性,维生素C作为术后脊柱疼痛的潜在治疗选择引起了人们的兴趣。根据现有证据,维生素C可能对术后脊柱疼痛有有益影响,包括降低疼痛评分、减少镇痛药物用量以及降低诸如复杂性区域疼痛综合征等并发症的发生率。然而,需要更多研究来充分了解用于术后疼痛管理的维生素C补充剂的最佳剂量和持续时间。

结论

维生素C可被视为管理脊柱术后疼痛的一种潜在有益的辅助治疗方法,但其常规使用需要进一步研究。

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