Chaitanya Nallan Csk, Muthukrishnan Arvind, Krishnaprasad C M S, Sanjuprasanna Gali, Pillay Poojaragini, Mounika Balmoori
Department of Oral Medicine and Radiology, Research Scholar of Saveetha university, Saveetha University, Thandalam, India.
Department of Oral Medicine and Radiology, Saveetha Dental College, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):119-125. doi: 10.4103/jpbs.JPBS_12_18.
Pain is an unpleasant subjective feeling having implications on both physical and mental realm. Multiple dimensions of pain involving behavioral, spiritual, emotional, and cognitive changes have been studied and pathways elucidated. It is stressed that the nature in which pain is modulated and perceived at a higher center is a complex phenomenon. One of the main goals of pain modulation is to modify pain to a more tolerable level, rather than its complete eradication. Different pain management interventions were tried but have effects that are more adverse. Till date, the only reliable pain blockers are analgesics and anti-inflammatory drugs in the form of opioids and non-opioids. Despite this, most of the drugs are ineffective at various levels, furthermore, adding to complications. Thus, there is an urgent need for effective intervention with minimal side effects. Ascorbic acid, popularly known as vitamin C, has shown to exhibit promising analgesic properties. The literature is sparse with the usage of the drug in various forms of pain. This review focuses on the dynamics and kinetics of vitamin C and its usage in various forms of pain. With minimal adverse effects, the drug is shown to perform well in different types of pain disorders, thus paving way for alternative interventional agent for pain management.
疼痛是一种令人不快的主观感觉，对身体和精神领域都有影响。已经研究了疼痛的多个维度，包括行为、精神、情感和认知变化，并阐明了相关途径。需要强调的是，疼痛在高级中枢被调节和感知的本质是一个复杂的现象。疼痛调节的主要目标之一是将疼痛减轻到更可耐受的程度，而不是完全消除它。人们尝试了不同的疼痛管理干预措施，但效果大多更不理想。迄今为止，唯一可靠的疼痛阻滞剂是阿片类和非阿片类形式的镇痛药和抗炎药。尽管如此，大多数药物在不同层面上效果不佳，而且还会引发并发症。因此，迫切需要副作用最小的有效干预措施。维生素C（俗称抗坏血酸）已显示出有前景的镇痛特性。关于该药物在各种疼痛形式中的使用，相关文献较少。本综述聚焦于维生素C的动力学和动态变化及其在各种疼痛形式中的应用。该药物副作用极小，在不同类型的疼痛病症中表现良好，从而为疼痛管理的替代干预药物铺平了道路。
