Afzalipour Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Clinical Informatics Research and Development Lab, Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Allergy Asthma Immunol. 2024 Apr 7;23(2):127-138. doi: 10.18502/ijaai.v23i2.15317.
The tragic COVID-19 pandemic affected many children worldwide. Among the factors that may influence the course of viral infections including COVID-19, it is still uncertain whether atopy has a protective or predisposing role. The study aims to address the knowledge gap by investigating the prevalence and severity of COVID-19 among atopic children in Kerman, in 2022. A descriptive-analytical cross-sectional study on children with a history of atopy was performed in Kerman Medical University. Demographic information, type of atopy (including allergic rhinitis, Hyper-Reactive Airway Disease (HRAD) or asthma, eczema, urticaria, anaphylaxis, and food allergy), history of COVID-19 infection, and disease severity were recorded. A total of 1007 children and adolescents, (boys: 56.4%, girls: 43.6%, age:5.61±2.64 years) were included in the study. History of COVID-19 infection was positive in 53.5%, with 75.9% of the cases exhibiting mild disease severity. The frequency of atopies was HRAD or asthma (67.2%), allergic rhinitis (42.6%), and food allergy (27.4%). The frequency of COVID-19 cases was significantly higher among patients with HRAD or asthma, whereas it was significantly lower among those with food allergies, anaphylaxis, and eczema. Among atopic individuals, COVID-19 severity was significantly lower in those with allergic rhinitis, while the opposite trend was observed among food-allergic individuals. This study sheds light on the relationship between atopy and COVID-19 among pediatric patients. It seems specific types of atopies may influence the risk and severity of COVID-19 infection differently. A better understanding of these associations can inform clinical management and preventive measures for vulnerable pediatric populations.
2022 年，在伊朗克尔曼，我们开展了一项描述性分析性的横断面研究，旨在调查患有特应性的儿童中 COVID-19 的患病率和严重程度。研究纳入了在克尔曼医科大学有特应性病史的儿童。记录了人口统计学信息、特应性类型（包括过敏性鼻炎、高反应性气道疾病（HRAD）或哮喘、湿疹、荨麻疹、过敏反应和食物过敏）、COVID-19 感染史和疾病严重程度。共有 1007 名儿童和青少年（男孩：56.4%，女孩：43.6%，年龄：5.61±2.64 岁）纳入了本研究。COVID-19 感染史阳性者占 53.5%，其中 75.9%的病例为轻症。HRAD 或哮喘（67.2%）、过敏性鼻炎（42.6%）和食物过敏（27.4%）是最常见的特应性疾病。HRAD 或哮喘患者 COVID-19 病例的发生率显著更高，而食物过敏、过敏反应和湿疹患者的发生率显著更低。在特应性个体中，过敏性鼻炎患者 COVID-19 的严重程度显著较低，而食物过敏患者的情况则相反。本研究阐明了儿科患者中特应性与 COVID-19 之间的关系。似乎特定类型的特应性可能会以不同的方式影响 COVID-19 感染的风险和严重程度。更好地了解这些关联可以为脆弱的儿科人群提供临床管理和预防措施的信息。
