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大量儿科药物配给——一项针对 200 多万瑞典儿童的全国性研究。

Considerable paediatric drug dispensing - A nationwide study of more than 2 million Swedish children.

机构信息

Swedish Medical Products Agency, Uppsala, Sweden.

Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.

出版信息

Acta Paediatr. 2024 Sep;113(9):2147-2154. doi: 10.1111/apa.17305. Epub 2024 Jun 1.

Abstract

AIM

The aim of the nationwide study was to describe paediatric drug utilisation in Sweden.

METHODS

Drug prescriptions dispensed to all children aged 0-17 years in 2019 were analysed using data from the Swedish National Prescribed Drug Register.

RESULTS

We retrieved data on 2 180 508 unique children. Nearly 4.6 million prescriptions were dispensed to children aged 0-17 years, and 52% of these were to boys. Just under half of the children (47%) were dispensed at least one drug: 48% of girls and 45% of boys (p < 0.01). More than a third (34%) were dispensed three or more different drugs during 2019. The number of dispensed prescriptions per 1000 children was higher in boys than girls up to 12 years of age (p < 0.01), and the opposite trend was observed from 13 years and above, even when we excluded contraceptives (p < 0.01). The most common therapeutic areas were drugs for the respiratory tract (25%), namely antihistamines, antiasthmatics and cough medication. These were followed by psychoanaleptics and melatonin for the nervous system (19%) and dermatologicals (16%), namely cortisone creams and emollients.

CONCLUSION

Paediatric drug use was common, and a considerable proportion of children were dispensed multiple drugs.

摘要

目的

全国性研究的目的是描述瑞典儿科药物的使用情况。

方法

使用瑞典国家处方药物登记处的数据,分析了 2019 年所有 0-17 岁儿童的药物处方。

结果

我们检索到了 2180508 名独特儿童的数据。向 0-17 岁儿童开出了近 460 万张处方,其中 52%是给男孩的。将近一半(47%)的儿童至少开了一种药物:女孩为 48%,男孩为 45%(p<0.01)。超过三分之一(34%)的儿童在 2019 年期间服用了三种或更多不同的药物。男孩的处方数(每 1000 名儿童)高于女孩,直至 12 岁(p<0.01),而在 13 岁及以上,即使排除避孕药(p<0.01),也观察到相反的趋势。最常见的治疗领域是呼吸道药物(25%),即抗组胺药、抗哮喘药和止咳药。其次是神经科药物和褪黑素(19%)和皮肤科药物(16%),即皮质类固醇乳膏和保湿剂。

结论

儿科药物的使用很常见,相当一部分儿童开了多种药物。

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