• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

桦木醇油对甲状腺功能减退症患者毛发生长的影响：一项长期、盲法的初步研究。

Effect of betulin oil on hair growth in hypothyroidism- a long-term blinded pilot study.

机构信息

Department of Immunochemistry and Chemistry, Wrocław Medical University, M. Skłodowskiej-Curie Street 48/50, 50-369, Wrocław, Poland.

Faculty of Prevention and Health, Medical College Ul. Nowowiejska, 69 50-340, Wrocław, Poland.

出版信息

Arch Dermatol Res. 2024 Jun 1;316(6):318. doi: 10.1007/s00403-024-02913-5.

DOI:10.1007/s00403-024-02913-5
PMID:38822862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144158/
Abstract

BACKGROUND

One common problem in various patient groups is excessive hair loss on the head. One such group is people struggling with hypothyroidism. The market for preparations for hair growth and hair loss prevention includes betulin.

PURPOSE

This pilot study investigated its effect on hair loss in hypothyroid patients.

STUDY DESIGN

The study included a group of hypothyroid patients and a control group of people without hypothyroidism. Participants were randomly divided into a group taking placebo and betulin.

METHODS

Results were investigated using photographic assessment of hair, trichoscopy and subjective evaluation of participants.

CONCLUSION

The study did not conclusively prove that betulin would contribute to the inhibition of hair loss or regrowth.

摘要

背景

各种患者群体中一个常见的问题是头部过度脱发。其中一个群体是患有甲状腺功能减退症的人。用于促进头发生长和预防脱发的制剂市场包括桦木醇。

目的

本初步研究调查了它对甲状腺功能减退症患者脱发的影响。

研究设计

该研究包括一组甲状腺功能减退症患者和一组没有甲状腺功能减退症的对照组。参与者被随机分为安慰剂和桦木醇组。

方法

使用头发摄影评估、毛发镜检查和参与者的主观评估来调查结果。

结论

该研究并未明确证明桦木醇会有助于抑制脱发或再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/3e2c972d599a/403_2024_2913_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/6eba2d8f342e/403_2024_2913_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/fbe0f5dc31a1/403_2024_2913_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/3e2c972d599a/403_2024_2913_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/6eba2d8f342e/403_2024_2913_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/fbe0f5dc31a1/403_2024_2913_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d45/11144158/3e2c972d599a/403_2024_2913_Fig3_HTML.jpg

相似文献

1
Effect of betulin oil on hair growth in hypothyroidism- a long-term blinded pilot study.桦木醇油对甲状腺功能减退症患者毛发生长的影响：一项长期、盲法的初步研究。
Arch Dermatol Res. 2024 Jun 1;316(6):318. doi: 10.1007/s00403-024-02913-5.
2
Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines.白桦脂酸、白桦脂醇和桦树皮提取物的理化比较及其对皮肤表皮癌细胞（A431）、乳腺癌细胞（MCF7）和宫颈腺癌（HeLa）细胞系的体外细胞毒性作用研究。
Nat Prod Res. 2012;26(10):968-74. doi: 10.1080/14786419.2010.545352. Epub 2011 May 27.
3
Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract.使用含锯叶棕提取物的局部用产品治疗男性雄激素性脱发。
Australas J Dermatol. 2016 Aug;57(3):e76-82. doi: 10.1111/ajd.12352. Epub 2015 May 25.
4
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study.多模态米诺地尔微乳剂与单用米诺地尔治疗混合病因雄激素性脱发的制备与评价：一项试点研究。
Drug Des Devel Ther. 2013 May 30;7:413-23. doi: 10.2147/DDDT.S43481. Print 2013.
5
Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: a pilot study.拉坦前列素对短尾猕猴秃头皮毛发生长的影响：一项初步研究。
Acta Derm Venereol. 2002;82(1):7-12. doi: 10.1080/000155502753600803.
6
A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia.一项随机、双盲、安慰剂对照的初步研究，旨在评估用 0.1%拉坦前列素进行为期 24 周的局部治疗对雄激素性脱发的健康志愿者的毛发生长和色素沉着的疗效。
J Am Acad Dermatol. 2012 May;66(5):794-800. doi: 10.1016/j.jaad.2011.05.026. Epub 2011 Aug 27.
7
Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling.白桦脂醇和白桦脂酸通过抑制活性氧（ROS）、细胞因子（TNF-α、TGF-β）的产生以及影响细胞内信号转导来减轻乙醇诱导的肝星状细胞激活。
Toxicology. 2011 Feb 27;280(3):152-63. doi: 10.1016/j.tox.2010.12.006. Epub 2010 Dec 21.
8
Impact of a topical lotion, CG428, on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomized double-blind controlled clinical trial (VOLUME RCT).一种局部外用药 CG428 对乳腺癌幸存者永久性化疗所致脱发的影响：一项随机双盲对照临床试验（VOLUME RCT）。
Support Care Cancer. 2020 Apr;28(4):1829-1837. doi: 10.1007/s00520-019-04982-z. Epub 2019 Jul 23.
9
Nourkrin: objective and subjective effects and tolerability in persons with hair loss.纽克林：对脱发患者的客观与主观影响及耐受性
J Int Med Res. 2006 Sep-Oct;34(5):514-9. doi: 10.1177/147323000603400508.
10
Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.褪黑素可提高雄激素性脱发或弥漫性脱发女性的生长期毛发率：一项初步随机对照试验的结果。
Br J Dermatol. 2004 Feb;150(2):341-5. doi: 10.1111/j.1365-2133.2004.05685.x.

引用本文的文献

1
Betulinic Acid-Loaded Oleogel as a Novel Pharmaceutical Formulation for Potential Cutaneous Applications: Development, Characterization, and Biosafety Profile.负载桦木酸的油凝胶作为一种潜在的皮肤应用新型药物制剂：开发、表征及生物安全性概况
Life (Basel). 2025 Jun 13;15(6):954. doi: 10.3390/life15060954.

本文引用的文献

1
Study of the efficacy of carboxytherapy in alopecia.羧基疗法治疗脱发的疗效研究。
J Cosmet Dermatol. 2018 Dec;17(6):1275-1285. doi: 10.1111/jocd.12501. Epub 2018 Feb 20.
2
Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.通过一种新型两阶段方法鉴定出成纤维细胞生长因子5（FGF5）抑制化合物后，在临床环境中促进毛发生长期、增加头发密度并减少脱发。
Clin Cosmet Investig Dermatol. 2017 Feb 27;10:71-85. doi: 10.2147/CCID.S123401. eCollection 2017.
3
Medicinal plants of the genus Betula--traditional uses and a phytochemical-pharmacological review.
桦木属药用植物——传统用途及植物化学-药理学综述
J Ethnopharmacol. 2015 Jan 15;159:62-83. doi: 10.1016/j.jep.2014.11.010. Epub 2014 Nov 18.
4
Neuroendocrinology of the hair follicle: principles and clinical perspectives.毛囊的神经内分泌学：原理与临床视角。
Trends Mol Med. 2014 Oct;20(10):559-70. doi: 10.1016/j.molmed.2014.06.002. Epub 2014 Jul 21.
5
A Descriptive Study of Alopecia Patterns and their Relation to Thyroid Dysfunction.脱发模式及其与甲状腺功能障碍关系的描述性研究。
Int J Trichology. 2013 Jan;5(1):57-60. doi: 10.4103/0974-7753.114701.
6
Conditioning in laser skin resurfacing - betulin emulsion and skin recovery.激光皮肤重建中的调理 - 白桦脂醇乳液和皮肤恢复。
J Craniomaxillofac Surg. 2013 Apr;41(3):249-53. doi: 10.1016/j.jcms.2012.10.003. Epub 2012 Dec 23.
7
The hair follicle as a dynamic miniorgan.毛囊作为一个动态的微小器官。
Curr Biol. 2009 Feb 10;19(3):R132-42. doi: 10.1016/j.cub.2008.12.005.
8
Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells.桦木醇与黑皮质素受体结合，并拮抗α-黑素细胞刺激素诱导的小鼠黑素瘤细胞中环磷酸腺苷（cAMP）的生成。
Cell Biochem Funct. 2007 Sep-Oct;25(5):591-6. doi: 10.1002/cbf.1427.
9
Hair follicle bulge: a fascinating reservoir of epithelial stem cells.毛囊隆突部：上皮干细胞的迷人储存库。
J Dermatol Sci. 2007 May;46(2):81-9. doi: 10.1016/j.jdermsci.2006.12.002. Epub 2007 Jan 5.
10
Birch bark research and development.桦树皮研发
Nat Prod Rep. 2006 Dec;23(6):919-42. doi: 10.1039/b606816b. Epub 2006 Sep 18.