Cooke T D, Sumi M, Maeda M
Clin Orthop Relat Res. 1985 Mar(193):235-45.
Immune complexes were detected by plain and immunoelectron microscopy amongst electron-dense material that rapidly formed and extended over and into the cartilaginous surfaces of immune arthritic rabbits' knees. The sinuous extension of electron-dense material into the surface matrix was associated with fragmentation and detachment, resulting in erosions. The findings implicate the formation of immune complexes in the destructive process of the matrix. Since the eroded pannus-free matrix of rheumatoid cartilage surfaces contains extensive concentrations of immune complexes, the data of this immune arthritis model suggest a causative relation between immune complexes and matrix loss in rheumatoid arthritis.
通过普通电子显微镜和免疫电子显微镜在电子致密物质中检测到免疫复合物，这些物质迅速形成并延伸至免疫性关节炎兔膝关节的软骨表面并深入其中。电子致密物质蜿蜒延伸至表面基质与碎片形成和脱离相关，从而导致侵蚀。这些发现表明免疫复合物在基质的破坏过程中形成。由于类风湿性软骨表面无血管翳的侵蚀基质中含有大量免疫复合物，该免疫性关节炎模型的数据表明免疫复合物与类风湿性关节炎中基质丢失之间存在因果关系。
