Cooke T D, Sumia M, Elliott S, Maeda M
J Rheumatol Suppl. 1983 Dec;11:103-7.
Antigen-induced arthritis of rabbits is used as a model to study pannus-free destruction of cartilage in rheumatoid arthritis (RA) by transmission and scanning electron microscopy, incorporating plain and immune labeling techniques. During the acute "arthus" phase of the RA, immune complexes form and persist in these tissues. We observed the progressive formation of electron dense material rich in immune complexes within a millimicron of the hyaline cartilage surfaces that preceded erosion and loss of surface tissue. Polymorphonuclear neutrophils congregated at the cartilage margins to engulf immune complexes at and within the cartilage surfaces. The changes occurred in regions of hyaline and fibrocartilage free of pannus. Immune complex formation appeared to be a central feature of the cartilage destructive changes, and may be central to mechanisms of tissue loss and similar to those observed in RA.
兔抗原诱导性关节炎被用作模型，通过透射电子显微镜和扫描电子显微镜，结合普通和免疫标记技术，研究类风湿性关节炎（RA）中软骨无血管翳破坏的情况。在RA的急性“阿瑟斯”阶段，免疫复合物在这些组织中形成并持续存在。我们观察到，在透明软骨表面出现侵蚀和表面组织丢失之前，在距透明软骨表面一微米范围内逐渐形成富含免疫复合物的电子致密物质。多形核中性粒细胞聚集在软骨边缘，吞噬软骨表面及表面内的免疫复合物。这些变化发生在无血管翳的透明软骨和纤维软骨区域。免疫复合物的形成似乎是软骨破坏变化的核心特征，可能是组织丢失机制的核心，并且与RA中观察到的情况相似。
