Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh.
Laboratory of Agro - Biotechnology and Nutrition in Semi-Arid Zones, Faculty of Nature and Life Sciences, University of Ibn Khaldoun, Tiaret, Algeria.
Neurochem Res. 2024 Aug;49(8):1926-1944. doi: 10.1007/s11064-024-04177-x. Epub 2024 Jun 1.
Neurodegeneration, the decline of nerve cells in the brain, is a common feature of neurodegenerative disorders (NDDs). Oxidative stress, a key factor in NDDs such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease can lead to neuronal cell death, mitochondria impairment, excitotoxicity, and Ca stress. Environmental factors compromising stress response lead to cell damage, necessitating novel therapeutics for preventing or treating brain disorders in older individuals and an aging population. Synthetic medications offer symptomatic benefits but can have adverse effects. This research explores the potential of flavonoids derived from plants in treating NDDs. Flavonoids compounds, have been studied for their potential to enter the brain and treat NDDs. These compounds have diverse biological effects and are currently being explored for their potential in the treatment of central nervous system disorders. Flavonoids have various beneficial effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic, and antioxidant properties. Their potential to alleviate symptoms of NDDs is significant.
神经退行性变是大脑神经细胞的衰退，是神经退行性疾病（NDDs）的一个共同特征。氧化应激是阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和亨廷顿病等 NDD 的一个关键因素，它会导致神经元细胞死亡、线粒体损伤、兴奋性毒性和钙应激。破坏应激反应的环境因素会导致细胞损伤，因此需要为老年人和老龄化人口预防或治疗大脑疾病开发新的治疗方法。合成药物提供了对症治疗的益处，但可能会产生不良反应。本研究探讨了源自植物的类黄酮治疗 NDD 的潜力。类黄酮化合物因其有可能进入大脑并治疗 NDD 而受到研究。这些化合物具有多种生物学作用，目前正在探索它们在治疗中枢神经系统疾病方面的潜力。类黄酮具有多种有益的作用，包括抗病毒、抗过敏、抗血小板、抗炎、抗肿瘤、抗凋亡和抗氧化作用。它们缓解 NDD 症状的潜力是显著的。
